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Clvs1/2 antibody (C-Term)

Clvs1/2 Reactivity: Human, Mouse, Rat IF, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN784598
  • Target
    Clvs1/2 (Clavesin 1/2 (Clvs1/2))
    Binding Specificity
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    Specific for the ~35 kDa Clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are Clavesin 1 and 2, respectively.
    Cross-Reactivity (Details)
    Species reactivity (expected):Human and Mouse.
    Species reactivity (tested):Rat.
    Purification
    Affinity Chromatography.
    Immunogen
    Synthetic peptide KLH-conjugated corresponding to amino acid residues from the C-terminal region of Rat Clavesin-1. Genename: CLVS1/2
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 50 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at -20 °C.
  • Target
    Clvs1/2 (Clavesin 1/2 (Clvs1/2))
    Background
    Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).Synonyms: C6orf212, C6orf213, CLVS1, CLVS2, CRALBPL, Cellular retinaldehyde-binding protein-like, RLBP1L1, RLBP1L2, Retinaldehyde-binding protein 1-like 1/2
    Gene ID
    366311
    NCBI Accession
    NP_001102439
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