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COPA Products

(Coatomer Protein Complex, Subunit alpha (COPA))

Categories

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008].

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Featured COPA Categories

COPA Antibodies

High quality antibodies with extensive validation data.

COPA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended COPA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (5)
Cat. No. ABIN7266423
Quantity 100 μL
Datasheet Datasheet

Application WB, IHC, ICC, IHC (p)
Validations
  • (2)
Cat. No. ABIN337288
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN560436
Quantity 50 μL
Datasheet Datasheet

Recommended COPA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350036
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3091922
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136483
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our COPA products

Watkin, Jessen, Wiszniewski, Vece, Jan, Sha, Thamsen, Santos-Cortez, Lee, Gambin, Forbes, Law, Stray-Pedersen, Cheng, Mace, Anderson, Liu, Tang, Nicholas, Nahmod, Makedonas, Canter, Kwok, Hicks et al.: "COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. ..." in: Nature genetics, Vol. 47, Issue 6, pp. 654-60, (2015) (PubMed).

Li, Custer, Gilson, Hao, Beattie, Androphy: "α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth." in: Human molecular genetics, Vol. 24, Issue 25, pp. 7295-307, (2015) (PubMed).

Ting, Wen, Liu, Hsieh-Li, Li, Lin-Chao: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." in: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).

Synonyms and alternative names related to COPA

coatomer protein complex subunit alpha (COPA), WD40 repeat-containing protein (copA), coatomer protein complex subunit alpha (cgd8_860), coatomer protein complex subunit alpha (Chro.80105), Coatomer subunit alpha (AFUA_3G08840), coatomer protein complex subunit alpha (copa), coatomer protein complex, subunit alpha (copa), coatomer protein complex subunit alpha (Copa), coatomer protein complex subunit alpha L homeolog (copa.L), AU040324, cb281, COPA, DDBDRAFT_0189693, DDBDRAFT_0233797, DDB_0189693, DDB_0233797, DKFZp469O221, fb13c12, HEP-COP, wu:fb13c12, xenin

Protein level used designations for COPA

  • coatomer protein complex, subunit alpha
  • coatomer protein complex alpha subunit
  • coatomer protein complex subunit alpha
  • Coatomer subunit alpha
  • coatomer subunit alpha
  • alpha-COP
  • alpha-coat protein
  • HEPCOP
  • alpha coat protein
  • proxenin
  • xenin
  • sneezy
  • HEP-COP
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