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Expression of GCRG213p, LINE-1 endonuclease variant, significantly different in gastric complete and incomplete intestinal metaplasia
This current study has indicated the role of ERCC1 upregulation in drug resistance development under 5-FU-induced cytotoxicity in AGS gastric cancer cells.
Correlations between loss of expression of three genes: CETN2 (P < 0.001) and ERCC1 (P = 0.01) from the nucleotide excision repair (NER) and NEIL2 (P = 0.04) from the base excision repair (BER) pathways were associated with endocrine treatment resistance in discovery dataset, and subsequently validated in independent patient cohorts.
The binding of SLX4IP to both SLX4 and XPF-ERCC1 not only is vital for maintaining the stability of SLX4IP protein, but also promotes the interaction between SLX4 and XPF-ERCC1, especially after DNA damage. Collectively, these results demonstrate a new regulatory role for SLX4IP in maintaining an efficient SLX4-XPF-ERCC1 complex in interstrand crosslinks (ICLs) repair.
ERCC1 expression was significantly related to mismatch repair status only in non-mucinous colorectal carcinoma cases.
ERCC1 expression has no predictive value for survival in cases locally advanced stage with NPC. Evaluation of ERCC1 expression is not appropriate with a biomarker to detect cases who can benefit from PCT in NPC.
ERCC1 C8092A (rs3213986) in 3'UTR of ERCC1 was associated with an increased risk of lung cancer, especially in smoking population, and therefore could be used as a valuable tumor marker.
The expression levels of TUBB3, ERCC1 and P-gp in ovarian cancer tissues were significantly higher than those in adjacent normal tissues (p<0.05).
ERCC-1 gene was not associated with the proliferation of ovarian cancer cells
Studied role of zinc finger protein 326 (ZNF326) in promotion of excision repair cross-complementation group 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) cells.
we investigated how specific XPF mutations found in patients affected with xeroderma pigmentosum(XP) , XP combined with Cockayne syndrome or Fanconi anemia impair the activity of the ERCC1-XPF complex in response to DNA damage induction by UV irradiation. We show that XPF with an XP mutation is inefficiently recruited into the NER machinery but retains repair activity
ERCC1 polymorphisms may affect non-small cell lung cancer risk in the Polish population.
found significant over-expression of the double strand break-fidelity genes CDKN1A and ERCC1, independent of promoter methylation and associated with chemorefractoriness in chronic myelomonocytic leukaemia
a combination of ERCC1 and ERCC2 polymorphisms may predict overall survival among pemetrexed/platinum treated advanced non-squamous non-small-cell lung cancer patients
ERCC1 (C118T (rs11615) and C8092A (rs3212986)) and ERCC2 (A751C (rs171140) and G312A (rs1799793)) polymorphisms were analysed in 44 patients with osteosarcoma.
The single-nucleotide polymorphisms in ERCC1 and AFP genes may affect the prognosis of hepatocellular carcinoma, offering reliable information for early prediction of tumor progression and diagnosis.
high expression of ERCC1 was identified as an independent factor associated with worse overall survival in metastatic bladder cancer
The results indicated that polymorphisms in nucleotide excision repair genes ERCC1, XPC and ERCC2 might influence ovarian cancer susceptibility.
NDRG1 disruption alleviates cisplatin/sodium glycididazole-induced DNA damage response and apoptosis in ERCC1-defective lung cancer cells
Single nucleotide polymorphism rs11615 in ERCC1 gene confers susceptibility to coronary artery disease and severity of coronary atherosclerosis in a Chinese Han population.
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation (LPO) implicates LPO-induced DNA damage
chronic treatment of Ercc1(-/) mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology.
Dietary tryptophan restriction increased microbial diversity and made the gut microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice.
ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER disorders.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 loss-associated Snail reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2
These results show that mice, in which the defect in DNA repair is limited to neurons, develop an age-related impairment of context-dependent fear learning.
we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.
Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.
Performed metabolic profiling of serum and urine of the ERCC1(d/-) mouse, which has a modified ERCC1 gene, in comparison to wild type ERCC1 mice and in relation to aging by (1)H NMR spectroscopy.
Results suggest that the repair functions of Ercc1 are required in both male and female germ cells at all stages of their maturation.
ERCC1 is not required for immunoglobulin class switching
Data reveal an unanticipated involvement of the ERCC1/XPF NER endonuclease in the regulation of telomere integrity.
mitomycin C triggered sister chromatid exchanges in wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant cells, indicating that in their absence, repair of double-strand breaks(DSBs)is prevented.
ERCC1 and XPF protect short telomeres from homologous recombination.
These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair 1
, excision repair cross-complementing 1
, excision repair protein
, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)