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Our findings firstly show that the T allele of ERCC1 rs11615 can serve as a predictive biomarker for breast cancer and TNBC. We believe that ERCC1 could serve as a target for personalized treatment of breast cancer, especially for TNBC.
Data suggest that miR1385p regulates the sensitivity of gastric cancer cells to cisplatin, possibly by modulating expression of the DNA repair proteins ERCC1 and ERCC4.
Results provide evidence that ERCC1 contributes to FTO/beta-catenin induced chemo-radiotherapy resistance in cervical squamous cell carcinoma.
Study provides evidence that Replication forks can break quickly in S-phase upon DNA replication stress induction by an endonucleolytic mechanism independent of MUS81. Two nucleases ARTEMIS and XPF-ERCC1 are responsible for this Rapid-Replication Fork Breakage (RRFB) which takes place during S and G2 phases of the cell cycle.
ERCC1-transfected HCT-116 cells showed paradoxical behaviour in vivo with increased growth in mice treated with oxaliplatin as compared to untreated mice.
Patients with advanced non-small cell lung cancer (NSCLC) displaying low expression of excision repair cross-complementation group 1 (ERCC1) benefit from cisplatin-based chemotherapy. High expression of ERCC1 indicates better progression-free survival in the treatment with erlotinib/bevacizumab supporting the prognostic impact.
Five of these SNPs acted as cis-eQTLs, being associated with the transcription of IREB2 (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (rs6495309) and ERCC1 (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis genomic variants that regulate their transcription.
We found that patients with positive ERCC1 expression and deficient (d)MMR status had higher overall survival (OS) than those with either positive ERCC1 and pMMR, negative ERCC1 and dMMR, or negative ERCC1 expression and pMMR status (OS 79 vs. 69 vs. 66 vs. 61%, hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.80-1.00; p = 0.043).
Gene expression study along with DNA sequence analysis show that different splicing isoforms of ERCC1 affect the expression of its overlapping genes CD3EAP and PPP1R13L.
common genetic variations in ERCC1/XPF genes predispose to neuroblastoma risk, which needs to be further validated by ongoing efforts.
ERCC1 rs3212986 CC genotype showed a protective effect against radiotherapy-induced acute reactions.
Our results indicated a link between ERCC1 rs3212986 and the onset of late gastrointestinal toxicity ..No association was found regarding the XRCC3 rs861539 polymorphism and any clinical toxicity event
ERCC1 overexpression is an important phenotype that is associated with esophageal squamous cell carcinoma (ESCC) lymph node metastasis and advanced tumor clinical stages. ERCC1 expression may also inhibit ESCC cell apoptosis via regulating survivin expression, and ERCC1 and survivin overexpression are independent predictors of prognosis for ESCC patients who receive chemotherapy and/or radiotherapy.
ERCC1 expression might be a useful predictive marker in patients with locoregionally advanced nasopharyngeal carcinoma receiving cisplatin-based concurrent chemoradiotherapy
the present results indicate that the EGFR mutation status and TS and ERCC1 expression can be used as the predictors of overall survival after subsequent second-line treatments for adenocarcinoma non-small-cell lung cancer
In conclusion, these findings identified no association between rs11615 and rs2276466 polymorphisms and Colorectal Cancer(CRC) susceptibility, but the data indicate that ERCC1 rs3212986 and rs2298881 polymorphisms may increase susceptibility to CRC.
The polymorphisms of rs3212986 showed no association with the risk of preeclampsia in the Chinese Han population. However, the difference in the genotypic distribution between early-onset and late-onset preeclampsia suggest the need for future studies.
ERCC1 expression was not prognostic in surgically resected oropharynx/oral cavity squamous cell carcinoma of head and neck
A functional relationship of ERCC1 expression with genomic instability in prostate cancer.
in nasopharyngeal carcinoma patients, ERCC1 and BRCA1 may be a predictor of response to platinum-based chemotherapy and concurrent radiochemotherapy.
chronic treatment of Ercc1(-/) mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology.
Dietary tryptophan restriction increased microbial diversity and made the gut microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice.
ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER disorders.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 loss-associated Snail reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2
These results show that mice, in which the defect in DNA repair is limited to neurons, develop an age-related impairment of context-dependent fear learning.
we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.
Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.
Performed metabolic profiling of serum and urine of the ERCC1(d/-) mouse, which has a modified ERCC1 gene, in comparison to wild type ERCC1 mice and in relation to aging by (1)H NMR spectroscopy.
Results suggest that the repair functions of Ercc1 are required in both male and female germ cells at all stages of their maturation.
ERCC1 is not required for immunoglobulin class switching
Data reveal an unanticipated involvement of the ERCC1/XPF NER endonuclease in the regulation of telomere integrity.
mitomycin C triggered sister chromatid exchanges in wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant cells, indicating that in their absence, repair of double-strand breaks(DSBs)is prevented.
ERCC1 might be involved in processing or repair of DNA lesions in S regions during CSR.
ERCC1 and XPF protect short telomeres from homologous recombination.
These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair 1
, excision repair cross-complementing 1
, excision repair protein
, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)