Browse our ERCC8 Proteins (ERCC8)

Full name:: Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 Proteins (ERCC8)

On www.antibodies-online.com are 6 Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) Proteins from 0 different suppliers available. A total of 118 ERCC8 products are currently listed.

Synonyms:: 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18Rik, Ckn1, Csa, UVSS2, zgc:103550

list all proteins	Gene Name	GeneID	UniProt
Human ERCC8	ERCC8	1161	Q13216
Rat ERCC8	ERCC8	310071
Mouse ERCC8	ERCC8	71991	Q8CFD5
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Human Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) interaction partners

ERCC6 (show ERCC6 Proteins) rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk. The ERCC6 (show ERCC6 Proteins) rs1917799-ERCC8 rs158572 pair significantly influence ERCC6 (show ERCC6 Proteins) and ERCC6 (show ERCC6 Proteins)-ERCC8 expression.
Loss of Cockayne syndrome group A protein (CSA) or Cockayne syndrome group B protein (CSB (show ERCC6 Proteins)) leads to polymerase stalling at non-B DNA in a neuroblastoma (show ARHGEF16 Proteins) cell line, in particular at G-quadruplex structures.
The role of CSA in oxidative stress
Although the absence of CSA had no effect on CSB recruitment, CSA itself localized at sites of interstrand crosslinks, double-strand breaks and monoadducts but not at oxidative DNA lesions.
Our findings suggested that ERCC8 rs158572 and rs158916, alone or together with environmental factors, might be associated with gastric cancer and atrophic gastritis susceptibility.
A novel function of Cockayne syndrome A protein as transcription factor of RNA polymerase I (show POLR1C Proteins) in the nucleolus is shown.
Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations.
The role of CSA and CSB protein in the oxidative stress response.
The role of CSA protein in TC-NER (show NR1H2 Proteins) is described in this review
The review focuses on the participation of the CSB and CSA proteins in many different protein interactions and complexes, and how these interactions inform us about pathways that are defective in the disease.

Mouse (Murine) Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) interaction partners

MtDNA mutations are highly increased in cells from subcutaneous fat of aged Csa(-/-) mice
difference in oxidative DNA damage sensitivity between CSA- and CSB-deficient cell lines and mice

ERCC8 Protein Profile

Protein Summary

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

Alternative names and synonyms associated with ERCC8

excision repair cross-complementation group 8 (ercc8)
ERCC excision repair 8, CSA ubiquitin ligase complex subunit (ERCC8)
ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8)
excision repaiross-complementing rodent repair deficiency, complementation group 8 (Ercc8)

2410022P04Rik protein
2810431L23Rik protein
4631412O06Rik protein
B130065P18Rik protein
Ckn1 protein
Csa protein
UVSS2 protein
zgc:103550 protein

Protein level used designations for ERCC8

DNA excision repair protein ERCC-8 , Cockayne syndrome 1 protein , Cockayne syndrome WD-repeat protein CSA , cockayne syndrome WD repeat protein CSA , Cockayne syndrome 1 (classical) , excision repaiross-complementing rodent repair deficiency, complementation group 8 , Cockayne syndrome 1 homolog , cockayne syndrome WD repeat protein CSA homolog

GENE ID	SPECIES
449811	Danio rerio
427153	Gallus gallus
1161	Homo sapiens
487225	Canis lupus familiaris
518857	Bos taurus
310071	Rattus norvegicus
71991	Mus musculus

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