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ERCC6 (show ERCC6 Proteins) rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk. The ERCC6 (show ERCC6 Proteins) rs1917799-ERCC8 rs158572 pair significantly influence ERCC6 (show ERCC6 Proteins) and ERCC6 (show ERCC6 Proteins)-ERCC8 expression.
Loss of Cockayne syndrome group A protein (CSA) or Cockayne syndrome group B protein (CSB (show ERCC6 Proteins)) leads to polymerase stalling at non-B DNA in a neuroblastoma (show ARHGEF16 Proteins) cell line, in particular at G-quadruplex structures.
The role of CSA in oxidative stress
Although the absence of CSA had no effect on CSB recruitment, CSA itself localized at sites of interstrand crosslinks, double-strand breaks and monoadducts but not at oxidative DNA lesions.
Our findings suggested that ERCC8 rs158572 and rs158916, alone or together with environmental factors, might be associated with gastric cancer and atrophic gastritis susceptibility.
A novel function of Cockayne syndrome A protein as transcription factor of RNA polymerase I (show POLR1C Proteins) in the nucleolus is shown.
Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations.
The role of CSA and CSB protein in the oxidative stress response.
The role of CSA protein in TC-NER (show NR1H2 Proteins) is described in this review
The review focuses on the participation of the CSB and CSA proteins in many different protein interactions and complexes, and how these interactions inform us about pathways that are defective in the disease.
MtDNA mutations are highly increased in cells from subcutaneous fat of aged Csa(-/-) mice
difference in oxidative DNA damage sensitivity between CSA- and CSB-deficient cell lines and mice
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
DNA excision repair protein ERCC-8
, Cockayne syndrome 1 protein
, Cockayne syndrome WD-repeat protein CSA
, cockayne syndrome WD repeat protein CSA
, Cockayne syndrome 1 (classical)
, excision repaiross-complementing rodent repair deficiency, complementation group 8
, Cockayne syndrome 1 homolog
, cockayne syndrome WD repeat protein CSA homolog