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Human Polyclonal TDG Primary Antibody for IHC - ABIN967162
Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. in The Journal of biological chemistry 1996
Show all 4 Pubmed References
Human Polyclonal TDG Primary Antibody for ICC, IF - ABIN4358254
Huang, Lu, Ding, Chu, Hsu, Chen, Tsao, Chen, Lee, Shan, Chen: TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. in Oncogene 2016
Human Monoclonal TDG Primary Antibody for IHC, IHC (p) - ABIN4358257
Lin, Kang, Lu, Wang, Ma, Leung: A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity. in Biosensors & bioelectronics 2016
miR (show MYLIP Antibodies)-29b targets LPL (show LPL Antibodies) and TDG genes and regulates apoptosis and triglyceride production in mammary epithelial cells.
CRL4(Cdt2) targets thymine DNA glycosylase (TDG), a base excision repair enzyme that is involved in DNA demethylation
TDG gene knockdown could inhibit the differentiation of pig pre-adipocytes and affect the DNA methylation (show HELLS Antibodies) levels of certain transcription factors.
These findings suggest that the catalytic and scaffolding activities of TDG are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG complexes.
The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 (show TET3 Antibodies) over-expression and Tdg repression.
TDG, as a new coactivator, promotes beta-catenin (show CTNNB1 Antibodies)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Antibodies) in canonical Wnt (show WNT2 Antibodies) signaling.
Embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels.
data suggest that oxidation of 5-methylcytosine by Tet proteins followed by TDG-mediated base excision of 5-carboxylcytosine constitutes a pathway for active DNA demethylation
Results demonstrate that TDG is required for normal mammalian development and the establishment of proper promoter/enhancer DNA methylation (show HELLS Antibodies) patterns that are conducive to transcription during embryogenesis
TDG-dependent DNA repair has evolved to provide epigenetic stability in lineage committed cells
Association of CBP/p300 (show CREBBP Antibodies) acetylase and TDG links DNA repair and transcription.
binds SUM0-1; TDGb was also shown to interact with the promyelocytic leukemia protein (PML (show PML Antibodies)) in vitro as well as to colocalize with this protein to nuclear bodies in transfected cells
TDG sumoylation promotes intramolecular interactions with amino- and carboxy-terminal SUMO-1 (show SUMO1 Antibodies) binding motifs that dramatically alter the biochemical properties and subcellular localization of TDG
TET2 (show TET2 Antibodies)- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.
Results indicate how Thymine DNA glycosylase (TDG) employs an adaptable active site to excise a broad variety of nucleobases from DNA.
Results indicate the presence of base excision repair -dependent and base excision repair-independent functions of TDG, which are involved in regulation of cellular DNA damage responses and gene expression patterns.
findings indicate that sumoylation and SUMO binding are not essential for TDG-mediated excision and repair of 5-carboxylcytosine bases.
Data show that Ras protein regulates inhibitor of growth protein 4 (ING4 (show ING4 Antibodies))-thymine-DNA glycosylase (TDG)-Fas (show FAS Antibodies) protein axis to promote apoptosis resistance in pancreatic cancer.
A long TA repeat in the promoter region of IL28B (show IL28B Antibodies) was associated with spontaneous HCV clearance.
NEIL1 (show NEIL1 Antibodies) and NEIL2 (show NEIL2 Antibodies) cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover.
Computational modeling study investigated the glycosidic bond cleavage reaction in human thymine DNA glycosylase
levels of TET3 (show TET3 Antibodies) and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy
TDG releases the excised base from its tight product complex with abasic DNA, contrary to previous reports. Moreover, DNA-free TDG exhibits no significant binding to free nucleobases (uracil, thymine, 5-hydroxymethyluracil)
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
G/T mismatch-specific thymine DNA glycosylase
, G/T mismatch DNA glycosylase
, G/t mismatch-specific thymine DNA glycosylase
, thymine-DNA glycosylase
, G/T mismatch-specific thymine DNA glycosylase-like
, g/T mismatch-specific thymine DNA glycosylase-like
, C-JUN leucine zipper interactive protein JZA-3