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anti-Mouse (Murine) TP53BP1 Antibodies:
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Fish Polyclonal TP53BP1 Primary Antibody for ChIP, FACS - ABIN151770
Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. in Molecular cell 2004
Show all 313 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody for ICC, IF - ABIN152191
Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. in The Journal of cell biology 2007
Show all 75 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody for ChIP, ICC - ABIN151771
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004
Show all 74 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody for ICC, FACS - ABIN151311
Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. in The Journal of biological chemistry 2009
Show all 11 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody for FACS, IHC - ABIN1724820
Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. in Cancer research 2012
Show all 2 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody for FACS, IHC - ABIN1724821
Mok, Henderson: The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. in The international journal of biochemistry & cell biology 2012
Show all 2 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody for IF (p), IHC (p) - ABIN682993
Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. in The Journal of biological chemistry 2015
Human Polyclonal TP53BP1 Primary Antibody for ICC, IF - ABIN4252095
Kondratova, Watanabe, Marotta, Cannon, Segall, Serre, Tanaka: Replication fork integrity and intra-S phase checkpoint suppress gene amplification. in Nucleic acids research 2015
Fish Polyclonal TP53BP1 Primary Antibody for FACS, ICC - ABIN4276945
Sykora, Misiak, Wang, Ghosh, Leandro, Liu, Tian, Baptiste, Cong, Brenerman, Fang, Becker, Hamilton, Chigurupati, Zhang, Egan, Croteau, Wilson, Mattson, Bohr: DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. in Nucleic acids research 2015
this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination
Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (show BRCA1 Antibodies) do not show an increased susceptibility to tumors in the absence of 53BP1.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Antibodies) and 53BP1 were recruited to these sites. H2AX (show H2AFX Antibodies) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Antibodies) foci formation and DSB repair, whereas H2AX (show H2AFX Antibodies) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Antibodies) foci were small and DSBs were not efficiently repaired
Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (show SGMS1 Antibodies) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.
These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (show PRKDC Antibodies)-deficient telomeres throughout the cell cycle.
Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Antibodies) deficiency, which was not observed for heterochromatin-related proteins HP1beta (show CBX1 Antibodies) and BMI1 (show BMI1 Antibodies).
Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (show E2F1 Antibodies) target genes and allows pRb (show PGR Antibodies) activity to be effectively integrated with the DNA damage response.
study uncovers novel ATM (show ATM Antibodies)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection
Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (show RIF1 Antibodies) and PTIP (show PAXIP1 Antibodies).
Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination
The results may suggest that TP53BP1 and MFN1 (show MFN1 Antibodies) frameshift mutations and their intratumoral heterogeneity (ITH) could contribute to cancer development by inhibiting the TSG (show TWSG1 Antibodies) activities.
results highlight the interplay of RNF169 (show RNF169 Antibodies) with 53BP1 in fine-tuning choice of DSB repair pathways.
Despite the requirement of all three nucleoporins for accurate NHEJ, only Nup153 (show NUP153 Antibodies) is needed for proper nuclear import of 53BP1 and SENP1 (show SENP1 Antibodies)-dependent sumoylation of 53BP1. Data support the role of Nup153 (show NUP153 Antibodies) as an important regulator of 53BP1 activity and efficient NHEJ.
Results indicate that integrity of the nuclear localization signal is important for 53BP1 nuclear localization.
As shown in xenograft model of glioblastoma phosphorylation of 53BP1 by GSK3beta was indispensable for DNA double-strand break repair.
results suggest that there is a direct interaction between 53BP1 and MCMs, which is essential for 53BP1 chromatin fraction and foci formation in hepatoma HepG2 cells.
Results indicate that 53BP1 is a biomarker of response to anti-PARP (show COL11A2 Antibodies) therapy in the laboratory, and our DNA damage response gene signature may be used to identify patients who are most likely to respond to PARP (show COL11A2 Antibodies) inhibition.
the two cell lines exhibited relatively low protein expression levels of p53 (show TP53 Antibodies), lower levels of p53 (show TP53 Antibodies) and TPp53BP1 transcripts were detected in the K562/G cells. Taken together, these findings suggest that the resistance of CML (show BCR Antibodies) to the tyrosine kinase (show TXK Antibodies) inhibitor, imatinib, may be associated with persistent STAT5 (show STAT5A Antibodies)-mediated ROS (show ROS1 Antibodies) production, and the abnormality of the p53 (show TP53 Antibodies) pathway
These results reveal two distinct fork restart pathways, which are antagonistically controlled by 53BP1 and BRCA1 in a double-strand DNA break repair-independent manner.
Gamma-H2AX (show H2AFX Antibodies), phosphorylated KAP-1 (show CDKN3 Antibodies) and 53BP1 play an important role in the repair of heterochromatic radon-induced DNA double-strand breaks.
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).
tumor protein p53 binding protein 1
, tumor protein p53 binding protein, 1
, tumor suppressor p53-binding protein 1-like
, tumor protein p53 binding protein 1 (predicted), 5 prime
, tumor protein p53 binding protein 1 (predicted), 3 prime
, murine p53-binding protein
, p53-binding protein 1
, transformation related protein 53 binding-protein 1
, tumor suppressor p53-binding protein 1
, tumor protein 53-binding protein, 1
, tumor protein p53-binding protein, 1
, transformation related protein 53 binding protein 1