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anti-Human PTK2B Antibodies:
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177156 : Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed) Show all 6 Pubmed References
Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177155 : Avraham, Park, Schinkmann, Avraham: RAFTK/Pyk2-mediated cellular signalling. in Cellular signalling 2000 (PubMed) Show all 6 Pubmed References
Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705 : Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004 (PubMed) Show all 3 Pubmed References
Human PTK2B Primary Antibody for IHC - ABIN966926 : Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004 (PubMed) Show all 5 Pubmed References
Human Polyclonal PTK2B Primary Antibody for ICC, IF - ABIN4348749 : Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017 (PubMed)
Cow (Bovine) Polyclonal PTK2B Primary Antibody for WB - ABIN2779800 : Ling, Sheng, Braun: The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation. in American journal of physiology. Cell physiology 2004 (PubMed)
Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN966925 : : Fresh concepts in dental design. in Journal of the California Dental Association 2004 (PubMed) Show all 4 Pubmed References
Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745118 : Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015 (PubMed)
Results show that VEGFA (show VEGFA Antibodies) induces Pyk2 activation in mediating human retinal microvascular endothelial cell migration, sprouting and tube formation, and that Pyk2-mediated STAT3 (show STAT3 Antibodies) activation is required for hypoxia-induced retinal neovascularization.
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2 (show EPHX2 Antibodies)); both of which have been previously associated with AD as risk factors.
thrombin (show F2 Antibodies) binding to PAR-1 (show MARK2 Antibodies) receptor activated Gi-protein/c (show PROC Antibodies)-Src (show SRC Antibodies)/Pyk2/EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/p42/p44 (show PSMC6 Antibodies) MAPK (show MAPK3 Antibodies) cascade, which in turn elicited AP-1 (show FOSB Antibodies) activation and ultimately evoked MMP-9 (show MMP9 Antibodies) expression and cell migration in SK-N-SH cells.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (show RPS6KB1 Antibodies) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (show RPS6KB1 Antibodies) may potentially serve as therapeutic targets for PCa (show FLVCR1 Antibodies) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 Antibodies) in the crosstalk between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies)/Ca(2 (show CA2 Antibodies)+) signaling pathways upon Wnt3a (show WNT3A Antibodies) stimulation in differentiating hNPCs.
STIM1 (show STIM1 Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (show PTPRB Antibodies) and VE-cadherin (show CDH5 Antibodies) and hence increase endothelial permeability.
Ascites and CCL18 (show CCL18 Antibodies) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (show 0 Antibodies), a process in part mediated through the PI3-kinase (show PIK3CA Antibodies)-Akt/PKB (show AKT1 Antibodies) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (show 0 Antibodies) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Data provide evidence that activated PYK2 may function as a component of the microtubule organizing center to regulate spindle assembly during the meiotic process of mouse oocytes.
MMP-9 (show MMP9 Antibodies) activation by hypoxia requires LRP1 (show LRP1 Antibodies) and Pyk2 phosphorylation in fibroblasts.
results suggest that although Pyk2 and FAK (show PTK2 Antibodies) are involved in inflammasome activation, only Pyk2 directly phosphorylates ASC (show STS Antibodies) and brings ASC (show STS Antibodies) into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC (show STS Antibodies) speck formation and subsequent NLRP3 (show NLRP3 Antibodies) inflammation.
Osteoprotegerin (show TNFRSF11B Antibodies) may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 and Src (show SRC Antibodies) and their intracellular distribution in osteoclasts.
These results suggest that mechanical stimuli activate P2X7 (show P2RX7 Antibodies) might induce ECMPs expression through PYK2 except in the case of OPN (show SPP1 Antibodies) expression. Altogether, mechanical stimuli-induced ECMPs production might be implicated by extracellular ATP secretion or integrin via PYK2 activation.
Lineage-tracing of monocyte populations suggests that Pyk2 promotes apoptosis in BM monocytes, thereby acting as an important homeostatic regulator of turnover in these short-lived, innate immune cells.
Pyk2 selectively contributes to the coordination of phagocytosis-promoting signals downstream of CR3 (show ITGAM Antibodies), but is dispensable for FcgammaR-mediated phagocytosis
the findings suggest a model in which the oocyte is not a passive participant in fertilization, but instead responds to sperm contact by localized PYK2 signaling that promotes actin remodeling events required to physically incorporate the sperm head into the ooplasm (show NLRP5 Antibodies).
results show that Pyk2 contributes to cytotoxic T lymphocyte(CTL) migration by regulating detachment of CTL at the trailing edge, which could explain why Pyk2 is important for chemotactic and migratory responses.
Defects in Pyk2 suppress Kawasaki Disease-like experimental vasculitis, presumably through CXCL9 (show CXCL9 Antibodies)- and CXCL10 (show CXCL10 Antibodies)-dependent interference with neo-angiogenesis. Since Pyk2-KO mice show no life-threatening phenotype, Pyk2 may be a promising therapeutic molecular target for KD.
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , cellular adhesion kinase beta , protein tyrosine kinase 2 beta , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , fakb , protein tyrosine kinase 2.2 , protein tyrosine kinase 2aa , protein tyrosine kinase 2b
