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anti-Rat (Rattus) PTK2B Antibodies:
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177155
Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177156
Faure, Corvol, Toutant, Valjent, Hvalby, Jensen, El Messari, Corsi, Kadaré, Girault: Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons. in Journal of cell science 2007
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Human PTK2B Primary Antibody for IHC - ABIN966926
Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004
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Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705
Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004
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Cow (Bovine) Polyclonal PTK2B Primary Antibody for WB - ABIN2779801
Ling, Sheng, Braun: The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation. in American journal of physiology. Cell physiology 2004
Human Polyclonal PTK2B Primary Antibody for ICC, IF - ABIN4348749
Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017
Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN966925
: Fresh concepts in dental design. in Journal of the California Dental Association 2004
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362252
Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362858
Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001
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UVB-irradiated or aged mice skin revealed that mTORC2 (show CRTC2 Antibodies) activity was significantly upregulated which in turn increased Akt (show AKT1 Antibodies) activation and Akt (show AKT1 Antibodies)-dependent IkappaB kinase alpha (show CHUK Antibodies) (IKKalpha (show CHUK Antibodies)) phosphorylation, and The increased mTORC2 (show CRTC2 Antibodies) signaling pathway during skin aging were associated to NF-kappaB (show NFKB1 Antibodies) activation.
this study reveals the function of IL-15 (show IL15 Antibodies) in astrocyte survival via Akt (show AKT1 Antibodies) phosphorylation in response to OGD (show FGFR1 Antibodies)-induced damage.
This study demonstrates the neuroprotective effect of TSG (show TWSG1 Antibodies) on APP (show APP Antibodies) expression, suggesting that TSG (show TWSG1 Antibodies) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (show INS Antibodies) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt (show AKT1 Antibodies)) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (show SETDB1 Antibodies) regulates PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies)/FOXO1 (show FOXO1 Antibodies) pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha (show PPARGC1A Antibodies) expression in skeletal muscle cells through a mechanism involving PI3K-Akt (show AKT1 Antibodies)-FoxO1 (show FOXO1 Antibodies) but not p38 MAPK (show MAPK14 Antibodies) or Erk1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies) pathways.
Ablation of Cyclophilin D (show PPIF Antibodies) Results in an Activation of FAK (show PTK2 Antibodies), Akt (show AKT1 Antibodies), and ERK (show EPHB2 Antibodies) Pathways in the Mouse Heart.(
These results reveal a novel signaling network, the Sema4D (show SEMA4D Antibodies)-RhoA (show RHOA Antibodies)-Akt (show AKT1 Antibodies) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
This is perhaps the first report demonstrating that AKT1 signaling prevailing in the mesenchymal stem cells regulates hematopoietic stem cell functionality through various intercellular communication mechanisms.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (show RPS6KB1 Antibodies) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (show RPS6KB1 Antibodies) may potentially serve as therapeutic targets for PCa (show FLVCR1 Antibodies) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 Antibodies) in the crosstalk between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies)/Ca(2 (show CA2 Antibodies)+) signaling pathways upon Wnt3a (show WNT3A Antibodies) stimulation in differentiating hNPCs.
STIM1 (show STIM1 Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (show PTPRB Antibodies) and VE-cadherin (show CDH5 Antibodies) and hence increase endothelial permeability.
Ascites and CCL18 (show CCL18 Antibodies) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Antibodies)-Akt/PKB (show AKT1 Antibodies) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta