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Human Monoclonal CTH Primary Antibody for ELISA, WB - ABIN560521
Schicho, Krueger, Zeller, Von Weyhern, Frieling, Kimura, Ishii, De Giorgio, Campi, Schemann: Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. in Gastroenterology 2006
Show all 21 Pubmed References
Human Monoclonal CTH Primary Antibody for IHC (p), ELISA - ABIN560523
Siebert, Cantré, Eipel, Vollmar: H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K(ATP) channels. in American journal of physiology. Gastrointestinal and liver physiology 2008
Show all 7 Pubmed References
Human Monoclonal CTH Primary Antibody for ELISA, WB - ABIN560522
dEmmanuele di Villa Bianca, Sorrentino, Maffia, Mirone, Imbimbo, Fusco, De Palma, Ignarro, Cirino: Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 5 Pubmed References
Cow (Bovine) Polyclonal CTH Primary Antibody for WB - ABIN2782463
Moore, Malats, Rothman, Real, Kogevinas, Karami, García-Closas, Silverman, Chanock, Welch, Tardón, Serra, Carrato, Dosemeci, García-Closas: Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. in International journal of cancer. Journal international du cancer 2007
Show all 4 Pubmed References
Human Polyclonal CTH Primary Antibody for IF (p), IHC (p) - ABIN1387469
Shiina, Shima, Horii, Naitou, Nakamori, Sano, Shimizu: Inhibitory action of hydrogen sulfide on esophageal striated muscle motility in rats. in European journal of pharmacology 2016
Cow (Bovine) Polyclonal CTH Primary Antibody for IHC, WB - ABIN2782464
Yang, Cao, Wu, Wang: Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. in The Journal of biological chemistry 2004
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CSE (show CSE Antibodies) is expressed in intraplaque microvessels, and H2S is a stimulator of micro-angiogenesis in vitro. Due to this pro-angiogenic effect, high levels of CSE (show CSE Antibodies) in atherosclerotic plaques may be a potential risk for plaque vulnerability.
Study demonstrated that lower abundance of cystathionine gamma-lyase expression and H2S production enhances type-2 immunoreaction and renders a higher incidence of allergic asthma at a young age.
MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine gamma-lyase in THP-1 (show GLI2 Antibodies) macrophages
Inducible expression of CBS (show CBS Antibodies) and CSE (show CSE Antibodies) was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.
Lipopolysaccharide increases the expression of CSE (show CSE Antibodies) in human macrophages, increasing H2S synthesis, via ERK (show EPHB2 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway.
Nox4 (show NOX4 Antibodies) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE (show CSE Antibodies) was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE (show CSE Antibodies)/H2S system is regulated by miR (show MLXIP Antibodies)-216a, and regulates ABCA1 (show ABCA1 Antibodies)-mediated cholesterol efflux and cholesterol levels through the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway.
Collectively, our findings indicate that radiation could promote HCC (show FAM126A Antibodies) cell invasion through EMT (show ITK Antibodies) mediated by endogenous H2S/CSE (show CSE Antibodies) signaling via the p38MAPK (show MAPK14 Antibodies) pathway.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 (show HMOX1 Antibodies) expression, and a further reduction in H2S levels and CSE (show CSE Antibodies) expression.
The results of this study show that deletion of the cystathionine-gamma-lyase gene has no effects on hypoxia-induced changes in TASK K(+) channel (show KCNC4 Antibodies) activity.
CSE is critical for the progression of kidney fibrosis.
renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection
This study suggests that the CSE/H2S system is involved in the pathogenesis of obesity in mice.
Data show that CSE plays an important role as an inhibitor of inflammation in the liver by producing H2S from L-cysteine.
Study shows maintaining CSE expression is critically important for stress adaptation during posttraumatic acute lung injury and CS-induced COPD (show ARCN1 Antibodies), most likely in a gender-dependent manner.
CSE-derived H2S contributes to mouse uterus homeostasis. Sildenafil reduces uterus contractility and its effect involves CSE-derived H2S.
The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S
Cystathionine-Gamma-Lyase Gene Deletion is associated with reduced inflammation and liver damage.
this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen