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anti-Human CTH Antibodies:
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Human Monoclonal CTH Primary Antibody for ELISA, WB - ABIN560521
Schicho, Krueger, Zeller, Von Weyhern, Frieling, Kimura, Ishii, De Giorgio, Campi, Schemann: Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. in Gastroenterology 2006
Show all 21 Pubmed References
Human Monoclonal CTH Primary Antibody for IHC (p), ELISA - ABIN560523
Siebert, Cantré, Eipel, Vollmar: H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K(ATP) channels. in American journal of physiology. Gastrointestinal and liver physiology 2008
Show all 7 Pubmed References
Human Monoclonal CTH Primary Antibody for ELISA, WB - ABIN560522
dEmmanuele di Villa Bianca, Sorrentino, Maffia, Mirone, Imbimbo, Fusco, De Palma, Ignarro, Cirino: Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 5 Pubmed References
Human Polyclonal CTH Primary Antibody for IHC (p), WB - ABIN3042672
Shi, Guo, Shi, Yu, Song, Li: Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats. in Medical science monitor : international medical journal of experimental and clinical research 2016
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Mouse (Murine) Polyclonal CTH Primary Antibody for WB - ABIN3042770
Guo, Duan, Wang, Zhou, Li, Sun: Endogenous carbon monoxide downregulates hepatic cystathionine-γ-lyase in rats with liver cirrhosis. in Experimental and therapeutic medicine 2015
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Human Polyclonal CTH Primary Antibody for ICC, IHC (p) - ABIN3044240
Chen, Wang, Li, Jiang, Lu, Zhou: Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats. in Journal of diabetes research 2016
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Cow (Bovine) Polyclonal CTH Primary Antibody for WB - ABIN2782463
Moore, Malats, Rothman, Real, Kogevinas, Karami, García-Closas, Silverman, Chanock, Welch, Tardón, Serra, Carrato, Dosemeci, García-Closas: Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. in International journal of cancer. Journal international du cancer 2007
Show all 4 Pubmed References
Human Polyclonal CTH Primary Antibody for IF (p), IHC (p) - ABIN1387469
Shiina, Shima, Horii, Naitou, Nakamori, Sano, Shimizu: Inhibitory action of hydrogen sulfide on esophageal striated muscle motility in rats. in European journal of pharmacology 2016
Cow (Bovine) Polyclonal CTH Primary Antibody for IHC, WB - ABIN2782464
Yang, Cao, Wu, Wang: Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. in The Journal of biological chemistry 2004
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Constitutive S-sulfhydration of human antigen R (on Cys13) by cystathionine gamma lyase -derived H2S prevents its homodimerization and activity, which attenuates the expression of target proteins such as CD62E and cathepsin S, preserving endothelial function and delaying atherogenesis.
The CTH 1364 G>T polymorphism was not associated with coronary artery disease (CAD) in the studied Greek population. However, interestingly, a higher - if not significantly so - CTH 1364 TT genotype frequency was present in female CABG patients compared with female controls. Larger studies are necessary to conclude on the potential overall or gender-driven association between CTH 1364 G>T gene polymorphism and CAD.
MTHFR is critical for production of S-adenosyl-l-methionine (SAM), the principal methyl donor. A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and Alzheimer's disease
We also performed SNP analysis of H2S synthesizing enzymes and found a significant increase in cystathionine gamma-lyase (CTH) 1364G-T allele frequency in patients with cardiovascular disease compared to controls
CSE is expressed in intraplaque microvessels, and H2S is a stimulator of micro-angiogenesis in vitro. Due to this pro-angiogenic effect, high levels of CSE in atherosclerotic plaques may be a potential risk for plaque vulnerability.
Study demonstrated that lower abundance of cystathionine gamma-lyase expression and H2S production enhances type-2 immunoreaction and renders a higher incidence of allergic asthma at a young age.
MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine gamma-lyase in THP-1 macrophages
not upregulated in uterine artery endothelium and smooth muscle in estrogen-dominant physiological states
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.
Lipopolysaccharide increases the expression of CSE in human macrophages, increasing H2S synthesis, via ERK/NF-kappaB pathway.
Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE/H2S system is regulated by miR-216a, and regulates ABCA1-mediated cholesterol efflux and cholesterol levels through the PI3K/AKT pathway.
Collectively, our findings indicate that radiation could promote HCC cell invasion through EMT mediated by endogenous H2S/CSE signaling via the p38MAPK pathway.
3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase and cystathionine gamma-lyase.
GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.
The miR-30 family are potentially important regulators of cystathionine gamma-lyase gene expression.
The l-cysteine/cystathionine gamma lyase/hydrogen sulfide pathway is involved in melanoma progression.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
role of NF-kappaB in the upregulation of cystathionine-gamma-lyase in bladder pain accompanying cystitis
Cystathionine gamma lyase-H2S was a dominant H2S generating system in osteoclasts, while cystathionine beta-synthase did not generate H2S.
ZYZ-803 stimulated the expression of cystathionine gamma-lyase (CSE) for H2S generation and the activity of endothelial NO synthase (eNOS) for NO production.Blocking CSE and/or eNOS suppressed ZYZ-803-induced H2S and NO production and cardioprotection.
Golgi stress response elicited by monensin stimulates CSE by acting via ATF4 with characteristics distinguishable from the endoplasmic reticulum stress response
The results of this study show that deletion of the cystathionine-gamma-lyase gene has no effects on hypoxia-induced changes in TASK K(+) channel activity.
CSE is critical for the progression of kidney fibrosis.
renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection
This study suggests that the CSE/H2S system is involved in the pathogenesis of obesity in mice.
Data show that CSE plays an important role as an inhibitor of inflammation in the liver by producing H2S from L-cysteine.
Study shows maintaining CSE expression is critically important for stress adaptation during posttraumatic acute lung injury and CS-induced COPD, most likely in a gender-dependent manner.
CSE-derived H2S contributes to mouse uterus homeostasis. Sildenafil reduces uterus contractility and its effect involves CSE-derived H2S.
The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S
Cystathionine-Gamma-Lyase Gene Deletion is associated with reduced inflammation and liver damage.
this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions.
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo.
lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co
H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes
Endogenous cystathionine gamma-lyase/Hydrogen sulfide regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment
The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen