Browse our anti-Insulin Receptor Substrate 1 (IRS1) Antibodies

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

1. Acute loss of IRS1/IRS2 or inhibition of IR/IGF (show INSR Antibodies)1R in KRAS-mutant human NSCLC cells decreases the (show IRS2 Antibodies) uptake and lowers the intracellular levels of amino acids, while enhancing basal autophagy and sensitivity to autophagy and proteasome i (show TP53 Antibodies)nhibitors.

2. S6K1 (show RPS6KB1 Antibodies)-dependent IRS (show IARS Antibodies)-1pSer suppresses insulin (show INS Antibodies) signaling leading to insulin (show INS Antibodies) resistance, which is frequently observed in AD brains. Notably, miR (show MLXIP Antibodies)-200b/c transfection of SH-SY5Y cells reduced the levels of IRS (show IARS Antibodies)-1pSer. This finding indicates that miR (show MLXIP Antibodies)-200b/c has the potential to alleviate insulin (show INS Antibodies) resistance via modulation of S6K1 (show RPS6KB1 Antibodies)

3. Together, miR (show MLXIP Antibodies)-145 mimics suppress cell proliferation by targeting and inhibiting IRS1 expression to inhibit MAPK/ERK (show MAPK1 Antibodies) signaling pathways.

4. Data suggest that Y537S/D538G ESR1 (show ESR1 Antibodies) mutant breast cancer cell lines exhibit enhanced proliferation in response to IGF1 (show IGF1 Antibodies)/IGF1R (show IGF1R Antibodies) signaling; mechanism involves IRS1; here, knockdown of IRS1 attenuates enhanced IGF1 (show IGF1 Antibodies)/IGF1R (show IGF1R Antibodies) signaling response in ESR1 (show ESR1 Antibodies) mutant cells. (ESR1 (show ESR1 Antibodies) = estrogen receptor 1 (show ESR1 Antibodies); IGF1 (show IGF1 Antibodies) = insulin like growth factor 1 (show IGF1 Antibodies); IGF1R (show IGF1R Antibodies) = IGF1 (show IGF1 Antibodies) receptor; IRS1 = insulin receptor substrate 1)

5. The effect of PF may be associated with its role in inhibiting de novo lipid synthesis and in regulating the ROCK/IRS (show IARS Antibodies)/Akt (show AKT1 Antibodies) signalling pathways.

6. Gene expression for insulin receptor substrate 1 (IRS-1), protein kinase B (Akt-2) and glucose transporter 4 (GLUT-4 (show SLC2A4 Antibodies)) genes were evaluated by real time PCR.

7. Reduced insulin receptor substrate-1 (IRS-1) staining in lung adenocarcinoma tissue microarray displayed a significant survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene (show RAB1A Antibodies) homolog (KRAS) mutant subgroup.

8. This study examined the normal regional brain expression of IRS-1 and found a significant correlation with the volumetric associated with regional atrophy in Alzheimer's disease.

9. Data show that MIR126 induces autophagic flux in malignant mesothelioma (MM) cells by downregulating insulin receptor substrate-1 (IRS1) and disrupting the IRS1 signaling pathway.

10. IRS1/beta-Catenin (show CTNNB1 Antibodies) Axis Is Activated and Induces MYC (show MYC Antibodies) Expression in Acute Lymphoblastic Leukemia Cells

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

1. 'selective insulin (show INS Antibodies) resistance' is caused by the differential expression of Irs1 and Irs2 (show IRS2 Antibodies) in different zones of the liver

2. Lung-specific dual ablation of insulin receptor (show INSR Antibodies) substrates 1/2 (succumb to tumor burdenIrs1/Irs2 (show IRS2 Antibodies)) strongly suppresses tumor initiation and dramatically extends the survival of a mouse model of lung cancer with Kras activation and p53 (show TP53 Antibodies) loss. Mice with Irs1/Irs2 loss eventually.

3. Noise exposure led to enhanced JNK (show MAPK8 Antibodies) phosphorylation and IRS1 serine phosphorylation as well as reduced Akt (show AKT1 Antibodies) phosphorylation in skeletal muscles in response to exogenous insulin (show INS Antibodies) stimulation.

4. The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 (show SIRT1 Antibodies) activation, which in turn increases IRS1 phosphorylation and GLUT4 (show SLC2A4 Antibodies) translocation in myotubes.

5. Results show that lack of IRS1 prevents beta-cell apoptosis induced by ER stress, and promotes XBP-1 (show XBP1 Antibodies) instability secondary to proteasomal degradation.

6. Using two long-lived IIS models, namely Drosophila lacking three insulin (show INS Antibodies)-like peptides (dilp2 (show FLNA Antibodies)-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms

7. findings suggest that up-regulation of miR (show MLXIP Antibodies)-222 followed by reduction in IRS-1 expression may be a viable mechanism of insulin (show INS Antibodies) resistance in the liver

8. These results demonstrate the cooperative interaction between RPTPbeta (show PTPRZ1 Antibodies) and the IGF-I receptor (show IGF1R Antibodies) leading to a coordinated series of signaling events that are required for osteoblast differentiation. Our findings emphasize the important role IRS-1 plays in modulating these signaling events and confirm its essential role in facilitating osteoblast differentiation

9. EGCG significantly ameliorated insulin (show INS Antibodies) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (show BDNF Antibodies)) signaling pathways.

10. Pit1 (show POU1F1 Antibodies) deletion inhibited USP7 (show USP7 Antibodies)/IRS1 dissociation upon insulin (show INS Antibodies) stimulation.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Antibodies) genes regulates body weight in rabbits.

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

1. miR (show MYLIP Antibodies)-146a-5p targets porcine insulin receptor (show INSR Antibodies) and could inhibit its protein expression.

2. TBC1D4 (show TBC1D4 Antibodies), insulin receptor (show INSR Antibodies) and GLUT4 (show SLC2A4 Antibodies) showed altered expression in some tissues in pre-diabetic pigs.

3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Antibodies) and a decreased cell proliferation.