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Human Monoclonal SYK Primary Antibody for ICS - ABIN2689913
Abtahian, Guerriero, Sebzda, Lu, Zhou, Mocsai, Myers, Huang, Jackson, Ferrari, Tybulewicz, Lowell, Lepore, Koretzky, Kahn: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. in Science (New York, N.Y.) 2003
Show all 7 Pubmed References
Human Polyclonal SYK Primary Antibody for IHC - ABIN967119
Yagi, Suzuki, Hasegawa, Okumura, Ra: Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812). in Biochemical and biophysical research communications 1994
Show all 7 Pubmed References
Human Polyclonal SYK Primary Antibody for IHC - ABIN967120
Law, Sidorenko, Chandran, Draves, Chan, Weiss, Edelhoff, Disteche, Clark: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. in The Journal of biological chemistry 1994
Show all 6 Pubmed References
Human Monoclonal SYK Primary Antibody for ICS - ABIN1177213
Hong, Yankee, Harrison, Geahlen: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. in The Journal of biological chemistry 2002
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Human Polyclonal SYK Primary Antibody for IHC (p), WB - ABIN389670
Satoh, Tabunoki, Ishida, Yagishita, Jinnai, Futamura, Kobayashi, Toyoshima, Yoshioka, Enomoto, Arai, Saito, Arima: Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains. in Neuropathology : official journal of the Japanese Society of Neuropathology 2012
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Human Monoclonal SYK Primary Antibody for ELISA, WB - ABIN1724704
Abbal, Lambelet, Bertaggia, Gerbex, Martinez, Arcaro, Schapira, Spertini: Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions. in Blood 2006
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Human Monoclonal SYK Primary Antibody for ICC, IHC (p) - ABIN94475
Parravicini, Gadina, Kovarova, Odom, Gonzalez-Espinosa, Furumoto, Saitoh, Samelson, OShea, Rivera: Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. in Nature immunology 2002
Show all 8 Pubmed References
Human Monoclonal SYK Primary Antibody for IF, IHC (p) - ABIN120732
Amoui, Dráberová, Tolar, Dráber: Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors. in European journal of immunology 1997
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Human Monoclonal SYK Primary Antibody for IP, WB - ABIN2476650
Blais: [How to register in another province of Canada]. in L' Infirmière canadienne 1976
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Dog (Canine) Polyclonal SYK Primary Antibody for ELISA, WB - ABIN2476649
Isler: Probing the complex issues of AIDS. An ethical argument for voluntary AIDS testing. in Compendium (Newtown, Pa.) 1992
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In this article, the authors have shown that Natural killer cells can reduce their functional role through downregulation of Syk and Zap70 (show ZAP70 Antibodies) kinases.
DFNA5 (show DFNA5 Antibodies) variant is associated with tobacco- and HPV-mediated oral oncogenesis.
This study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of Ewing sarcoma.
Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy.
Results show that Syk activation occurs following Abeta (show APP Antibodies) deposition and the formation of tau pathological species. As Syk activation also promotes Abeta (show APP Antibodies) formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease.
study reports that neutrophils constitutively express various Src (show SRC Antibodies) family isoforms as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally
Cholesterol crystals activate specific cell signalling pathways which drive the production of inflammatory cytokines and degradative enzymes known to contribute to disease initiation and progression and are dependent on activation of Syk and PI3K (show PIK3CA Antibodies)
Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (show PLC Antibodies) gamma1 (PLCgamma1 (show PLCG1 Antibodies)) in osteogenesis and PLCgamma2 (show PLCG2 Antibodies) in adipogenesis.
AKT (show AKT1 Antibodies) and 14-3-3 (show YWHAQ Antibodies) proteins down-regulate the activity of several BCR (show BCR Antibodies)-associated components, including BTK (show BTK Antibodies), BLNK (show BLNK Antibodies) and SYK and also inhibit SYK's interaction with Importin 7 (show IPO7 Antibodies)
Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells.
Results indicate spleen tyrosine kinase (SYK) as an essential mediator of brown fat formation and function.
CD11b (show ITGAM Antibodies) promotes the differentiation of osteoclasts induced by RANKL (show TNFSF11 Antibodies) through the Syk signaling pathway.
Phosphorylation levels of 10 phosphosites in spleen tyrosine kinase (SYK) were increased following B cell receptor activation. 4 cluster regions, encompassing 8 phosphosites, were activated by mercury. Phosphorylation of tyrosine-342 and -346 residues were most sensitive to mercury exposure.
Syk kinase acts downstream of receptors controlling granule cells tangential migration
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (show BCR Antibodies)-proximal signals.
SYK could induce HO-1 (show HMOX1 Antibodies) expression by regulating the Akt (show AKT1 Antibodies) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase