neonatal Fc Receptor Proteins
(neonatal Fc Receptor (FcRn))
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
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35 results
FcRn
Origin: Mouse
Host: Escherichia coli (E. coli)
Recombinant
SDS, WB, ELISA
FcRn
Origin: Mouse
Host: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
SDS, WB, Imm, ELISA, AcA
Active
FcRn
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
FcRn
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
FcRn
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS, WB, Imm, PC
FcRn
Origin: Pig
Host: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Func
1 image
FcRn
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
FcRn
Origin: Human
Host: Yeast
Recombinant
> 90 %
SDS
1 image
FcRn
Origin: Cynomolgus
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
FcRn
Origin: Human
Host: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
FcRn
Origin: Cynomolgus
Host: Yeast
Recombinant
> 90 %
ELISA
1 image
FcRn
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
Latest Publications for our neonatal Fc Receptor Proteins
: "Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis." in: Nature communications, Vol. 13, Issue 1, pp. 662, (2022) (PubMed).: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).
: "Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18754-18763, (2020) (PubMed).
: "Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses." in: Molecular and cellular endocrinology, Vol. 477, pp. 103-111, (2019) (PubMed).
: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "Comparative studies of the serum half-life extension of a protein via site-specific conjugation to a species-matched or -mismatched albumin." in: Biomaterials science, Vol. 6, Issue 8, pp. 2092-2100, (2018) (PubMed).
: "Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody." in: The Journal of biological chemistry, Vol. 292, Issue 42, pp. 17449-17460, (2017) (PubMed).
: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." in: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).
: "Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS." in: Analytical chemistry, Vol. 88, Issue 8, pp. 4239-47, (2016) (PubMed).
: "Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor." in: Experimental eye research, Vol. 143, pp. 49-59, (2015) (PubMed).
Aliases for neonatal Fc Receptor Proteins
Fc fragment of IgG receptor and transporter (FCGRT) ProteinsFc fragment of IgG receptor and transporter (Fcgrt) Proteins
Fc receptor, IgG, alpha chain transporter (Fcgrt) Proteins
alpha-chain Proteins
FCRN Proteins
FcRn Proteins
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