Gasdermin A2 Protein (GSDMA2) (AA 1-443) (His tag)
custom-made
GSDMA2
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target
- Gasdermin A2 (GSDMA2)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-443
- Origin
- Mouse
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Gasdermin A2 protein is labelled with His tag.
- Purpose
- Predefined custom protein recombinant Gsdma2 Protein expressed in mammalian cells.
- Sequence
- MSMFEDVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG ARYVRTDYTL LDVLEPGSSP SDPTLLGNFS FKNMLDVRVE GDVEVPTMMK VKGTVGLSQS STLEVQMLSV APTALENLHM ERKLSADHPF LKEMREYKQN LYVVMEVVKA KQEVTLKRAS NAISKFSLNL PSLGLQGSVN HKEAVTIPKG CVLAYRVRQL IIYGKDEWGI PYICTDNMPT FNPLCVLQRQ GSTVQMISGE MHEDFKTLKK EVQQETQEVE KLSPVGRSSL LTSLSHLLGK KKELQDLEQM LEGALDKGHE VTLEALPKDV LLLKDAMDAI LYFLGALTEL SEEQLKILVK SLENKVLPVQ LKLVESILEQ NFLQDKEDVF PLRPDLLSSL GEEDQILTEA LVGLSGLEVQ RSGPQYTWNP DTCHNLCALY AGLSLLHLLS RDS Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- Gasdermin A2 (GSDMA2)
- Alternative Name
- Gsdma2
- Background
- Gasdermin-A2 (Gasdermin-2) [Cleaved into: Gasdermin-A2, N-terminal (GSDMA2-NT), Gasdermin-A2, C-terminal (GSDMA2-CT)],FUNCTION: [Gasdermin-A2]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon bacterial infection, specifically cleaved by some bacterial effector protein, releasing the N-terminal moiety (Gasdermin-A2, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9EST1}., FUNCTION: [Gasdermin-A2, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A2, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate. {ECO:0000250|UniProtKB:Q96QA5}.
- Molecular Weight
- 49.8 kDa
- UniProt
- Q32M21
- AlphaFold
- Q32M21
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