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A genome-wide association study provided suggestive evidence that the NDST3 variation predisposed patients to schizophrenia and bipolar disorder.
study provides evidence that the minor allele of rs11098403, an SNP near NDST3, is significantly associated with a reduced risk of schizophrenia in a Han Chinese population, further confirming the data obtained from Caucasians
A case-control study evaluating the entire genome for genes associated with the risk of schizophrenia and bipolar disorder demnstrated polymorphisms of NDST3 in case patients.
NDST3 function is not essential for development or adult homeostasis despite contributing to HS synthesis in a region-specific manner
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin.
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
, bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3-like
, GlcNAc N-deacetylase/ N-sulfotransferase 3
, N-HSST 3
, N-heparan sulfate sulfotransferase 3
, bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
, glucosaminyl N-deacetylase/N-sulfotransferase 3
, N-deacetylase/N-sulfotransferase 3