GPR68 Products
(G Protein-Coupled Receptor 68 (GPR68))
Categories
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).
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Featured GPR68 Categories
GPR68 Antibodies
High quality antibodies with extensive validation data.
Recommended GPR68 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7162351
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
IHC, IHC (p), IF, ICC
Validations
- (1)
- (2)
Cat. No.
ABIN1048863
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7162350
Quantity
100 μL
Datasheet
Datasheet
Recommended GPR68 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3115033
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3124580
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GPR68 products
: "Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 34, pp. 10738-43, (2015) (PubMed).: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).
: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." in: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).
: "Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 7, pp. 2643-8, (2005) (PubMed).
: "Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation." in: Journal of pharmacological sciences, Vol. 99, Issue 2, pp. 160-7, (2005) (PubMed).
Synonyms and alternative names related to GPR68
G protein-coupled receptor 68 (GPR68), G protein-coupled receptor 68 (LOC100348269), G protein-coupled receptor 68 (Gpr68), BB131428, GPR12A, GPR68, OGR1, Ogr1Protein level used designations for GPR68
- G protein-coupled receptor 68
- ovarian cancer G-protein coupled receptor 1-like
- G-protein coupled receptor 68
- ovarian cancer G protein-coupled receptor, 1
- ovarian cancer G-protein coupled receptor 1
- sphingosylphosphorylcholine receptor
- bRGR1
- g protein-coupled receptor RGR1
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