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Anacardic Acid

Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
Catalog No. ABIN7233231
  • Application
    Inhibition (Inh)
    Purpose
    HAT Inhibitor
    Characteristics
    Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 μM) and PCAF (IC50 = 5.0 μM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 μM) and -9. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB. When used at 125 μM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells.
    Purity
    >98 %
    Chemical Name
    2-Hydroxy-6-pentadecylbenzoic acid
    Formula
    C22H36O3
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    6-Pentadecylsalicylic acid, 6-PDSA,Cell adhesion,Epigenetics,Posttranslational modification,Cytokine,MAPK,Acetyltransferase,Protease,Immunology,Angiogenesis,Stem cells,Inflammation,Cancer,NFkappaB,Chromatin
    Molecular Weight
    348.5
    CAS-No
    16611-84-0
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