Quick Overview for Decitabine (ABIN7233248)
Chemical Name
Permeability
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Purpose
- DNA hypomethylation agent
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Characteristics
- Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines1. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells2. Induces differentiation and growth inhibition in IDH1 mutant glioma cells and decreases tumor growth in vivo3. An extremely useful reagent for inhibition of DNA methyltransferases in a variety of experimental systems including zebrafish embryos4. Cell permeable. Active in vivo.
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Purity
- >98 %
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Formula
- C8H12N4O4
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Solubility
- Soluble in DMSO (up to 25 mg/ml) or in Water (up to 11 mg/ml).
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Thapsigargin
67526-95-8 (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[ [(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutox y)azuleno[4,5-b]furan-7-yl octanoate.
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
GeldanamycinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
K252a97161-97-2 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.
YM-08Inh (2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
Okadaic acidInh 78111-17-8 9,10-Deepithio-9,10-didehydroacanthifolicin
CantharidinInh 56-25-7 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
NSC 663284Inh 383907-43-5 NSC-63284, 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
RK 682Inh 150627-37-5 RK-682, (R)-3-Hexadecanoyl-5-hydroxymethyltetronic acid, (R)-4-Hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone
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Restrictions
- For Research Use only
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Format
- Powder
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Storage
- -20 °C
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Storage Comment
- -20°C
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Background
- NSC-127716,Epigenetics,DNA methyltransferase,Stem cells,Cancer,DNA damage,Chromatin
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Molecular Weight
- 228.2
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CAS-No
- 2353-33-5
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