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Sirtinol

Inh Cell-permeable 410536-97-9 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

/ (Sirtinol)

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Catalog No. ABIN7233291

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Quick Overview for Sirtinol (ABIN7233291)

Application

Inhibition (Inh)

Chemical Name

2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

Permeability

Cell-permeable

Purpose

SIRT inhibitor

Characteristics

Selective sirtuin inhibitor which does not effect HDAC1, IC50 = 131, 38 and 68 μM for SIRT1, SIRT2 and Sir2P respectively1. Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells2. Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells3. Displays pro-inflammatory effects in adipocytes4. Cell permeable.

Purity

>98 %

Formula

C26H22N2O2

Solubility

Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml). Do not store solutions.
Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- Biotin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Herbimycin A
Inh 70563-58-5 [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

17-GMB-APA-GA
Inh [(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

TEMPO
Inh 2564-83-2 2,2,6,6-Tetramethylpiperidine 1-oxyl, 2,2,6,6-Tetramethyl-1-piperidinyloxy, free radical, (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl, 1,1,5,5-tetramethylpentamethylene nitroxide, 2,2,6,6-Tetramethylpiperidine-1-oxyl

Triacsin C
Inh 76896-80-5 (3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane

TPCK
Inh 402-71-1 N-(4-Chloro-3-oxo-1-phenyl-2-butanyl)-4-methylbenzenesulfonamide

Staurosporine
Inh 62996-74-1 (2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Powder

Precaution of Use

GHS – Classification
Skin corrosion/irritation (Category 2), H315
Serious eye damage/eye irritation (Category 2A), H319
Specific target organ toxicity-single exposure (Category 3): Respiratory system, H335

Storage

-20 °C

Storage Comment

-20°C / protect from light
Background

Epigenetics,Protein deacetylase,Stem cells,Posttranslational modification,Chromatin

Molecular Weight

394.5

CAS-No

410536-97-9

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