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anti-Human SMAD7 Antibodies:
anti-Mouse (Murine) SMAD7 Antibodies:
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Human Polyclonal SMAD7 Primary Antibody for IHC, IHC (p) - ABIN4354717
Roman-Blas, Stokes, Jimenez: Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. in Osteoarthritis and cartilage 2007
Show all 9 Pubmed References
Human Polyclonal SMAD7 Primary Antibody for WB - ABIN4354712
Kleiter, Pedré, Mueller, Poeschl, Couillard-Despres, Spruss, Bogdahn, Giegerich, Steinbrecher: Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis. in Journal of neuroimmunology 2007
Show all 4 Pubmed References
Human Polyclonal SMAD7 Primary Antibody for IHC (p), WB - ABIN3044025
Tao, Hu, Li, Liu, Wu, Li, Fu, Wei, Luo: Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor ?/Smad pathways. in Transplantation proceedings 2011
Show all 3 Pubmed References
Human Monoclonal SMAD7 Primary Antibody for IHC (p), ELISA - ABIN517666
Chen, Yang, Huang, Hsue, Lin et al.: Aberrant expression in multiple components of the transforming growth factor-?1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell ... in Oral oncology 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SMAD7 Primary Antibody for WB - ABIN2779418
Briones-Orta, Sosa-Garrocho, Moreno-Alvarez, Fonseca-Sánchez, Macías-Silva: SnoN co-repressor binds and represses smad7 gene promoter. in Biochemical and biophysical research communications 2006
Furthermore, MERS coronavirus induced apoptosis through upregulation of Smad7 and fibroblast growth factor 2 (FGF2 (show FGF2 Antibodies)) expression in both kidney and lung cells.
findings demonstrate TGF-beta (show TGFB1 Antibodies) enhances expression of USP26 (show USP26 Antibodies) and reinforces SMAD7 stability by limiting the ubiquitin-mediated turnover of SMAD7; clinically, loss of USP26 (show USP26 Antibodies) correlates with high TGF-beta (show TGFB1 Antibodies) activity and confers poor prognosis in glioblastoma; data identify USP26 (show USP26 Antibodies) as a novel negative regulator of the TGF-beta (show TGFB1 Antibodies) pathway and suggest that loss of USP26 (show USP26 Antibodies) expression may be an important factor in glioblastoma pathogenesis
In conclusion, our study demonstrated that COL1A2 (show COL1A2 Antibodies)-AS1 (show PTGDR Antibodies)/miR (show MLXIP Antibodies)-21/Smad (show SMAD1 Antibodies) pathway plays an important role in inhibiting hypertrophic scar formation, and suggested this novel pathway may be a new target for hypertrophic scar treatment.
Our data revealed the SMAD7 loci is associated with hepatocellular carcinoma susceptibility and its clinicopathologic development.
Smad7 expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 Antibodies) signaling and promotes NF-kappaB (show NFKB1 Antibodies)-mediated inflammatory signaling in these cells through increased expression of IKK-beta (show IKBKB Antibodies)
SMAD7 gene and specifically the allele C could be protective for colorectal cancer (CRC (show CALR Antibodies)). An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC (show CALR Antibodies) risk.
Smad7 inhibition diminishes interaction of PKR (show PKLR Antibodies) with protein kinase inhibitor p58 (p58 (show DNAJC3 Antibodies)(IPK)).
Smad7 regulates TGF-beta1 (show TGFB1 Antibodies) signaling via a negative feedback loop and mediates the interaction between TGF-beta1 (show TGFB1 Antibodies) and other signaling pathways; suggesting that Smad7 over expression may have therapeutic potential in ALL.
Missense variant in smad7 gene is associated with colorectal cancer.
ASPP2 (show TP53BP2 Antibodies) suppresses invasion, peritoneal dissemination and TGF-beta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.
a heterozygous deletion of SMAD7 results in an increased proliferation of Muller cell progenitors in the central retina at postnatal day 4, the time window when Muller cells differentiate in the mouse retina; this in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated Muller cells in the more developed retina
changes were associated with increased expression of the antifibrotic protein Smad7 and higher levels of sphingosine in Sphk2 (show SPHK2 Antibodies)(-/-) unilateral ureteral obstruction kidneys
Smad7 plays a protective role in acute kidney injury by preventing tubular epithelial cells from the G1 cell cycle arrest.
study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta (show TGFB1 Antibodies) and CLIC4 (show CLIC4 Antibodies), is a dominant inhibitor of Smad7 and enhances TGF-beta (show TGFB1 Antibodies) signaling
Pancreatic depletion of SMAD7 resulted in age-dependent increases in beta cell dysfunction with accelerated glucose intolerance, followed by overt diabetes.
The inverse correlation between Smad7 and AhR (show AHR Antibodies) expression helps to propagate inflammatory signals in the gut (show GUSB Antibodies) in Crohn's disease.
results indicate that miR (show MLXIP Antibodies)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathway by directly targeting Smad7 and Tcf7l2 (show TCF7L2 Antibodies)
microRNA-497 modulates breast cancer cell proliferation, invasion, and survival by targeting SMAD7.
results indicate that miR (show MLXIP Antibodies)-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7
Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders
Tril (show TRIL Antibodies) is a novel component of a Bmp-Gata2 (show GATA2 Antibodies) positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
cTid1 can bind to other members of the Smad (show SMAD1 Antibodies) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (show SCN4A Antibodies) domain
Smad7 has a role in Xenopus mesodermal and neural induction
SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.
MiR (show MYLIP Antibodies)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene
a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7.
Results suggest that myostatin (show MSTN Antibodies) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
MAD (mothers against decapentaplegic, Drosophila) homolog 7
, MAD homolog 8
, Mothers against decapentaplegic, drosophila, homolog of, 7
, SMAD, mothers against DPP homolog 7
, mothers against DPP homolog 8
, mothers against decapentaplegic homolog 7
, MAD homolog 7
, SMAD 7
, mothers against DPP homolog 7
, mothers against decapentaplegic homolog 8
, MAD, mothers against decapentaplegic homolog 7
, mothers against DPP 7
, mothers against decapentaplegic-like protein 7
, SMAD family member 7