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anti-Human NCOA1 Antibodies:
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Human Monoclonal NCOA1 Primary Antibody for BI, WB - ABIN968842
Oñate, Tsai, Tsai, OMalley: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. in Science (New York, N.Y.) 1995
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Human Monoclonal NCOA1 Primary Antibody for ChIP, IF - ABIN152353
Klinge, Jernigan, Mattingly, Risinger, Zhang: Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. in Journal of molecular endocrinology 2004
Show all 4 Pubmed References
Amphibian Polyclonal NCOA1 Primary Antibody for FACS, ICC - ABIN152700
Rogatsky, Zarember, Yamamoto: Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. in The EMBO journal 2001
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Human Polyclonal NCOA1 Primary Antibody for WB - ABIN151779
Heemers, Regan, Schmidt, Anderson, Ballman, Tindall: Androgen modulation of coregulator expression in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2009
Our findings directly associate the AR/NCOA1 complex with PRKD1 (show PRKD1 Antibodies) regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 (show SRC Antibodies) can impact osteoblast function in an estrogen receptor (show ESR1 Antibodies)-independent manner.
The pregnane X receptor (show NR1I2 Antibodies) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC Antibodies) coactivator.
miR (show MLXIP Antibodies)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (show TRAF4 Antibodies) and NCOA1 downstream of MEK (show MAP2K1 Antibodies)-C/EBP (show CEBPA Antibodies)-mediated leptin (show LEP Antibodies) and insulin (show INS Antibodies) signaling, and that insulin (show INS Antibodies) and/or leptin (show LEP Antibodies) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (show CALR Antibodies).
Results provide the first evidence that NCOA1 is a direct target of miR (show MLXIP Antibodies)-105-1 suggesting that NCOA1 and miR (show MLXIP Antibodies)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (show FAM126A Antibodies) patients.
Data suggest that steroid receptor (show ESR2 Antibodies) coactivators (NCOA1, NCOA2 (show NCOA2 Antibodies), NCOA3 (show NCOA3 Antibodies)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Antibodies) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (show HIF1A Antibodies) and AP-1 (show FOSB Antibodies)-mediated VEGFa (show VEGFA Antibodies) expression
miR (show MLXIP Antibodies)-137 has a role in targeting p160 (show MSH6 Antibodies) steroid receptor (show ESR2 Antibodies) coactivators SRC1 (show SRC Antibodies), SRC2 (show NCOA2 Antibodies), and SRC3 (show NCOA3 Antibodies) and inhibits cell proliferation
SRC-1 can impact osteoblast function in an estrogen receptor (show ESR1 Antibodies)-independent manner.
The results suggest that biochanin A activates RORgamma-dependent IL-17 (show IL17A Antibodies) transcription through the enhancement of STAT3 (show STAT3 Antibodies) phosphorylation and STAT3 (show STAT3 Antibodies)-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Antibodies)-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (show SFTPA1 Antibodies) and PAF (show KIAA0101 Antibodies) is crucial for this process
Consequently, SRC-1 null mice displayed low TAT (show TAT Antibodies) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (show TAT Antibodies) deficiency.
the effect of orchidectomy (ORX) on the expression of SRC-1
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1