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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
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Pig (Porcine) IL2 Protein expressed in - ABIN2965535
Stěpánová, Sinkora: The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs. in Developmental and comparative immunology 2011
Show all 6 Pubmed References
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488
Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014
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Human IL2 Protein expressed in - ABIN988056
Yu, Chen, Horton, Bansal, McElrath, Reichman, Goepfert, Jin: Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection. in Journal of medical virology 2006
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN988052
Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease. in Blood 2009
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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN804324
Mendoza-Naranjo, Saéz, Johansson, Ramírez, Mandakovic, Pereda, López, Kiessling, Sáez, Salazar-Onfray: Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN803864
Gakamsky, Luescher, Pramanik, Kopito, Lemonnier, Vogel, Rigler, Pecht: CD8 kinetically promotes ligand binding to the T-cell antigen receptor. in Biophysical journal 2005
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
interleukin-2 (IL-2) is a non-pancreatic autoimmune target in type 1 diabetes
The IL-2 AC genotype and C allele of IL-2 (-330A>C) gene polymorphisms could be potential protective factors and might reduce the risk of oral cancer in Indian population.
Data show that GIF (show GIF Proteins) (ORF117 ) serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of granulocyte macrophage colony-stimulating factor (GM-CSF (show CSF2 Proteins)) and interleukin-2 (IL-2).
CD4 (show CD4 Proteins)(+) T cells showed the greatest increase (threefold) in ORMDL3 (show ORMDL3 Proteins) expression in individuals carrying the asthma-risk alleles, where ORMDL3 (show ORMDL3 Proteins) negatively regulated interleukin-2 production. The asthma-risk variants rs4065275 and rs12936231 switched CTCF (show CTCF Proteins)-binding sites in the 17q21 locus.
The main mechanism of elimination of mesenchymal stromal cells is cytotoxicity of NK cells that depended on IL-2 production.
Uremia patients receiving maintenance hemodialysis with hospitalacquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP (show CRP Proteins), IL2 and TNFalpha (show TNF Proteins) levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients.
The simultaneous delivery of multiple proinflammatory payloads to the cancer site conferred protective immunity against subsequent tumor challenges. A fully human homolog of IL2-F8-TNF (show TNF Proteins)(mut (show MUT Proteins)), which retained selectivity similar to its murine counterpart when tested on human material, may open new clinical applications for the immunotherapy of cancer.
Study found that in SLE patients lymphocyte production of IL-2 did not decrease when compared with that of normal subjects.
Interactions among polymorphisms of IFN-gamma (show IFNG Proteins)+874 AA, IL-2-330 TT, IL-10 (show IL10 Proteins)-1082 AA, IL10 (show IL10 Proteins)--592 AC and IL-4 (show IL4 Proteins)-589 CC/CT significantly influenced the clinical progression of the subjects with hepatitis B virus and/or hepatitis C virus infection.
Peripheral blood Tregs failed to effectively utilize IL-2 and had relatively little STAT5 (show STAT5A Proteins) phosphorylation in active ankylosing spondylitis.
Each mutation decreased STAT5 (show STAT5A Proteins) binding and altered IL-2-induced Il2ra (show IL2RA Proteins) gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression.
Deleting IL-2 in CD11c(high)MHCII(+) cells induces spontaneous colitis resembling human inflammatory bowel disease.
a significant increase in plasma levels of IL-2, IFN-g (show IFNG Proteins) and TNF (show TNF Proteins)-g was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
WASp knockout mice controlled growth of A20 (show TNFAIP3 Proteins) lymphoma cells that naturally produced IL-2.
Tumor growth delays observed by tumor irradiation combined with MVA (show MYO5A Proteins)-MUC1 (show MUC1 Proteins)-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA (show MYO5A Proteins) empty vector.
IL-2 signalling is essential to prevent deletion of CD4SP CCR7 (show CCR7 Proteins)+ Helios (show ZNFN1A2 Proteins)+ thymocytes at a later developmental stage than Card11 (show CARD11 Proteins) is required to prevent deletion. The deletion prevented by IL-2 signalling occurs in a Foxp3 (show FOXP3 Proteins)-independent manner.
in vivo targeting of the TNF (show TNF Proteins) superfamily receptor TNFRSF25 (show TNFRSF25 Proteins) using the TL1A (show TNFSF15 Proteins)-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy.
IL-2 and IL-6 (show IL6 Proteins) work together to enhance influenza-specific CD8 (show CD8A Proteins) T cell generation responding to live influenza virus in aged mice and humans
Genetic ablation of the IL2Rbeta chain on CD8 (show CD8A Proteins)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (show CD244 Proteins) and Tim-3 (show HAVCR2 Proteins); precludes terminal differentiation of highly defective PD-1 (show PDCD1 Proteins)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (show IL7 Proteins)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 (show IL15 Proteins) as instigators of CD8 (show CD8A Proteins)(+) T-cell exhaustion during chronic viral infe...
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein