Browse our anti-SOCS3 (SOCS3) Antibodies

Zebrafish Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

1. we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (show SFPQ Antibodies) and Socs3a

2. stat3 (show STAT3 Antibodies)/socs3 pathway is a key response in all tissue regeneration in zebrafish.

3. Trpm7 (show TRPM7 Antibodies) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a pathway.

4. SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Antibodies) pathway by chemical inhibitors

5. The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.

6. in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Antibodies) and SOCS3 proteins.

Human Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

1. SOCS3 overexpression decreased JAK (show JAK3 Antibodies)-STAT3 (show STAT3 Antibodies) signaling pathway activity, declined Bcl-2 (show BCL2 Antibodies) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells

2. miR203 expression may be upregulated by IL17 (show IL17A Antibodies) stimulation, and miR203 is a positive regulator of IL17induced VEGF (show VEGFA Antibodies) secretion.

3. SOCS3 DNA methylation (show HELLS Antibodies) is associated with body weight and moderates the effect of cumulative stress on obesity.

4. SOCS3 was targeted by miR30a- 5p in allergic rhinitis

5. Cellular viability was significantly decreased, whereas IL6 (show IL6 Antibodies) and TNFalpha (show TNF Antibodies) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.

6. this study shows that Nrf2 (show GABPA Antibodies) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) cascade

7. SOCS-1 (show SOCS1 Antibodies), SOCS-2 (show SOCS2 Antibodies), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer

8. Our study showed that the expressions of HER2 (show ERBB2 Antibodies), STAT3 (show STAT3 Antibodies), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (show ERBB2 Antibodies) and STAT3 (show STAT3 Antibodies) and lower expression of SOCS3 predict poor prognosis of OC.

9. Authors found that SOCS3 and SOCS1 (show SOCS1 Antibodies) expression was reduced in vivo, in tumor lesions of BCC and SCC (show CYP11A1 Antibodies), as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22 (show IL22 Antibodies)-secreting TILs.

10. the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (show FAM126A Antibodies) patients receiving TACE (show ADAM17 Antibodies) therapy.

Pig (Porcine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

1. In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (show STAT3 Antibodies) and TNF receptor-associated factor 2 (show TRAF2 Antibodies), suggesting mechanisms by which SOCS3 inhibits IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) signaling.

2. SOCS3 is an important negative regulator of insulin (show INS Antibodies) signaling in porcine adipocytes.

Cow (Bovine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

1. Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.

2. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Antibodies) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Mouse (Murine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

1. Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections.

2. These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation.

3. In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.

4. SOCS3 was targeted by miR30a- 5p in allergic rhinitis

5. SOCS3 was upregulated in lung CD4 (show CD4 Antibodies)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.

6. findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle

7. The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (show IL6 Antibodies) and expression of sex hormones.

8. High SOCS3 expression is associated with glioma.

9. Mechanistic analysis indicated that E47 (show TCF3 Antibodies) activated expression of the transcription factor Spi-B (show SPIB Antibodies) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (show FOXP3 Antibodies) expression. These findings demonstrate that the balance of Id3 (show ID3 Antibodies) and E47 (show TCF3 Antibodies) controls the maintenance of Foxp3 (show FOXP3 Antibodies) expression in Treg cells and, thus, contributes to Treg cell plasticity.

10. Our results show, for the first time, that SOCS-3 regulates leptin (show LEP Antibodies)-induced responses in cartilage