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anti-Human SOCS3 Antibodies:
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Human Polyclonal SOCS3 Primary Antibody for ELISA, IF (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Show all 4 Pubmed References
Human Monoclonal SOCS3 Primary Antibody for ELISA, WB - ABIN2476543
Rychlíková, Démant: Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes. in Folia biologica 1975
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Human Polyclonal SOCS3 Primary Antibody for IHC, IHC (p) - ABIN4355049
Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014
Show all 2 Pubmed References
Human Polyclonal SOCS3 Primary Antibody for IHC, ELISA - ABIN1585262
van de Loo, Veenbergen, van den Brand, Bennink, Blaney-Davidson, Arntz, van Beuningen, van der Kraan, van den Berg: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. in Arthritis and rheumatism 2012
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN94467
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. in Endocrine-related cancer 2007
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Human Polyclonal SOCS3 Primary Antibody for ELISA, WB - ABIN262251
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
Human Monoclonal SOCS3 Primary Antibody for IF, IHC (p) - ABIN522456
Pierconti, Martini, Pinto, Cenci, Capodimonti, Calarco, Bassi, Larocca: Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. in The Prostate 2011
Human Polyclonal SOCS3 Primary Antibody for WB - ABIN1883384
Kim, Kim, Liu, Cao, Chen: Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. in The Journal of biological chemistry 2008
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (show SFPQ Antibodies) and Socs3a
stat3 (show STAT3 Antibodies)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Antibodies) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Antibodies) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Antibodies) and SOCS3 proteins.
miR (show MLXIP Antibodies)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (show TGFB1 Antibodies) signalling via STAT1 (show STAT1 Antibodies)/SOCS3.
Data show that miR (show MLXIP Antibodies)-222-3p targeted SOCS3 genes and down-regulation of SOCS3 correlated with an increased expression of STAT3 (show STAT3 Antibodies) activation.
increased SOCS3 in combined IL-33 (show IL33 Antibodies) heterozygotes and minor allele homozygotes may be relevant for hay (show GTF2H5 Antibodies) fever development
In summary, this study has shown that LIF (show LIF Antibodies) is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (show STAT3 Antibodies)/SOCS3 signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Data suggest that SOCS3 is an important signaling protein in CLL, and Hsp90 (show HSP90 Antibodies) inhibitors represent an approach to target transcriptional repression in B cell lymphoproliferative disorders.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (show IFNA Antibodies) on hepatocellular carcinoma cell proliferation through activation of the JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling pathway by inhibiting SOCS3 expression.
SOCS3 was down-regulated in CML cell lines and most of BMNCs from CML patients, and the expression level of SOCS3 was associated with the inhibition of cell proliferation and drug resistance of CML cells.
SOCS3 is involved in suppression of Helicobacter pylori induced STAT3 (show STAT3 Antibodies) phosphorylation by docosahexaenoic acid pretreatment.
The increased miR (show MLXIP Antibodies)-203 expression is associated with the reduced anti-inflammatory mediator SOCS-3 expression and the increased endothelial adhesion molecule (show NCAM1 Antibodies) expression in maternal vessel endothelium in preeclampsia.
Our results show, for the first time, that SOCS-3 regulates leptin (show LEP Antibodies)-induced responses in cartilage
SOCS3 is an important negative regulator of insulin (show INS Antibodies) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Antibodies) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (show IL6 Antibodies) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (show TCF3 Antibodies) activated expression of the transcription factor Spi-B (show SPIB Antibodies) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (show FOXP3 Antibodies) expression. These findings demonstrate that the balance of Id3 (show ID3 Antibodies) and E47 (show TCF3 Antibodies) controls the maintenance of Foxp3 (show FOXP3 Antibodies) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (show RBL1 Antibodies), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO (show MRPS12 Antibodies)) HSCs.
Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein)
Cell type-specific, different roles for viral immediate early (show JUN Antibodies) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (show SOCS1 Antibodies) and SOCS3 during murine cytomegalovirus infection.
oncostatin M (show OSM Antibodies) mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (show IL17A Antibodies) and IL-21 (show IL21 Antibodies); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3 (show STAT3 Antibodies), and STAT5 (show STAT5A Antibodies); observations suggest that OSM (show OSM Antibodies) can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3 (show STAT3 Antibodies), and STAT5 (show STAT5A Antibodies)
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3