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anti-Human SOCS3 Antibodies:
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Human Polyclonal SOCS3 Primary Antibody for ELISA, IF (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Show all 4 Pubmed References
Human Monoclonal SOCS3 Primary Antibody for ELISA, WB - ABIN2476543
Rychlíková, Démant: Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes. in Folia biologica 1975
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Human Polyclonal SOCS3 Primary Antibody for IHC, IHC (p) - ABIN4355049
Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014
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Human Polyclonal SOCS3 Primary Antibody for IHC (p), WB - ABIN3044272
Wan, Che, Kang, Wu: SOCS3 blocks HIF-1? expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3. in Molecular medicine reports 2015
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Human Monoclonal SOCS3 Primary Antibody for IF, IHC (p) - ABIN522456
Pierconti, Martini, Pinto, Cenci, Capodimonti, Calarco, Bassi, Larocca: Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. in The Prostate 2011
Human Polyclonal SOCS3 Primary Antibody for WB - ABIN1883384
Kim, Kim, Liu, Cao, Chen: Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. in The Journal of biological chemistry 2008
Human Polyclonal SOCS3 Primary Antibody for ELISA, WB - ABIN262251
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN94467
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. in Endocrine-related cancer 2007
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we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (show SFPQ Antibodies) and Socs3a
stat3 (show STAT3 Antibodies)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Antibodies) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Antibodies) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Antibodies) and SOCS3 proteins.
Low SOCS3 expression is associated with invasion and lymph node metastasis in gastric cancer.
Results show the CAT haplotype in SOCS3 was associated with metabolic syndrome (MetS (show ETV3 Antibodies)) in Mexican Mestizos, and type 2 diabetes in Mexican Amerindians.
SOCS3 overexpression decreased JAK (show JAK3 Antibodies)-STAT3 (show STAT3 Antibodies) signaling pathway activity, declined Bcl-2 (show BCL2 Antibodies) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells
miR203 expression may be upregulated by IL17 (show IL17A Antibodies) stimulation, and miR203 is a positive regulator of IL17induced VEGF (show VEGFA Antibodies) secretion.
SOCS3 DNA methylation (show HELLS Antibodies) is associated with body weight and moderates the effect of cumulative stress on obesity.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (show IL6 Antibodies) and TNFalpha (show TNF Antibodies) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (show GABPA Antibodies) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) cascade
SOCS-1 (show SOCS1 Antibodies), SOCS-2 (show SOCS2 Antibodies), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (show ERBB2 Antibodies), STAT3 (show STAT3 Antibodies), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (show ERBB2 Antibodies) and STAT3 (show STAT3 Antibodies) and lower expression of SOCS3 predict poor prognosis of OC.
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (show STAT3 Antibodies) and TNF receptor-associated factor 2 (show TRAF2 Antibodies), suggesting mechanisms by which SOCS3 inhibits IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) signaling.
SOCS3 is an important negative regulator of insulin (show INS Antibodies) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Antibodies) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Our findings suggest a role for murine cytomegalovirus (MCMV)-related stimulation of SOCS1 (show SOCS1 Antibodies) and SOCS3 in the progression of retinal disease during ocular, but not systemic, MCMV infection.
Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections.
These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation.
In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.
SOCS3 was upregulated in lung CD4 (show CD4 Antibodies)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (show IL6 Antibodies) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (show TCF3 Antibodies) activated expression of the transcription factor Spi-B (show SPIB Antibodies) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (show FOXP3 Antibodies) expression. These findings demonstrate that the balance of Id3 (show ID3 Antibodies) and E47 (show TCF3 Antibodies) controls the maintenance of Foxp3 (show FOXP3 Antibodies) expression in Treg cells and, thus, contributes to Treg cell plasticity.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3