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SensoLyte® 520 Cathepsin K Assay Kit

FRET Fluorometric
Catalog No. ABIN1882445
  • Target See all Cathepsin K (CTSK) Kits
    Cathepsin K (CTSK)
    Detection Method
    Fluorometric
    Application
    Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Brand
    SensoLyte®
    Characteristics
    The SensoLyte® 520 Cathepsin K Activity Assay Kit uses a QXL™ 520/HiLyte Fluor™ 488 FRET peptide substrate for the measurement of enzyme activity. In the intact FRET peptide, the fluorescence of HiLyte Fluor™ 488 is quenched by QXL™ 520. Upon cleavage of the FRET peptide by the active enzyme, the increase of fluorescence can be continuously monitored at excitation/emission = 490/520 nm. The fluorescent signal from HiLyte Fluor™ 488 is stable at low pH, which is optimal for cathepsin activity. The kit can be used to detect the activity of Cathepsin K enzyme in biological samples and purified enzyme preparations.
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  • Comment

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Handling Advice
    Protect Components A and B from light and moisture.
    Storage
    -80 °C
    Storage Comment
    Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Component D can be stored at room temperature for convenience
  • Target
    Cathepsin K (CTSK)
    Alternative Name
    Cathepsin K (CTSK Products)
    Synonyms
    CTS02 Kit, CTSO Kit, CTSO1 Kit, CTSO2 Kit, PKND Kit, PYCD Kit, AI323530 Kit, MMS10-Q Kit, Ms10q Kit, catK Kit, CTSK Kit, wu:fa95f03 Kit, wu:fb08b05 Kit, zgc:110367 Kit, cts02 Kit, ctso Kit, ctso1 Kit, ctso2 Kit, pknd Kit, pycd Kit, OC-2 Kit, catk Kit, cathepsin K Kit, cathepsin K L homeolog Kit, Cathepsin K Kit, CTSK Kit, Ctsk Kit, ctsk Kit, ctsk.L Kit, catk Kit
    Background
    Cathepsins are a class of globular lysosomal proteases playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.
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