TIMP3 ELISA Kit

Catalog No. ABIN5510570

Product Details TIMP3 ELISA Kit

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Binding Specificity: AA 24-211

Reactivity: Horse

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of horse equine TIMP-3

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: C24-P211

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Sequence similarities: Belongs to the protease inhibitor I35 (TIMP) family.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Alternative Name: TIMP3 (TIMP3 Products)

Synonyms: TIMP-3 ELISA Kit, TIMP3 ELISA Kit, timp3 ELISA Kit, HSMRK222 ELISA Kit, K222 ELISA Kit, K222TA2 ELISA Kit, SFD ELISA Kit, IMP-3 ELISA Kit, timp3-A ELISA Kit, Timp-3 ELISA Kit, metalloproteinase inhibitor 3 ELISA Kit, TIMP metallopeptidase inhibitor 3 ELISA Kit, Metalloproteinase inhibitor 3 ELISA Kit, TIMP metallopeptidase inhibitor 3 L homeolog ELISA Kit, tissue inhibitor of metalloproteinase 3 ELISA Kit, CpipJ_CPIJ003282 ELISA Kit, TIMP3 ELISA Kit, timp3 ELISA Kit, Timp3 ELISA Kit, timp3.L ELISA Kit

Background:

Protein Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Background: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).

Synonyms: Metalloproteinase inhibitor 3,Protein MIG-5,Tissue inhibitor of metalloproteinases 3,TIMP-3,TIMP3,

Full Gene Name: Metalloproteinase inhibitor 3

Cellular Localisation: Secreted, extracellular space, extracellular matrix.

UniProt: P35625