-
- Target See all GZMB ELISA Kits
- GZMB (Granzyme B (GZMB))
- Binding Specificity
- AA 21-247
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Reactivity
- Mouse
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Granzyme B
- Brand
- PicoKine™
- Analytical Method
- Quantitative
- Specificity
- Expression system for standard: NSO, Immunogen sequence: I21-S247
- Cross-Reactivity (Details)
- There is no detectable cross-reactivity with other relevant proteins.
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Granzyme B (GZMB) ELISA Kit
GZMB Reactivity: Human Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Granzyme B (GZMB) ELISA KitGZMB Reactivity: Mouse Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Granzyme B (GZMB) ELISA KitGZMB Reactivity: Rat Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Granzyme B (GZMB) ELISA KitGZMB Reactivity: Monkey Colorimetric Sandwich ELISA 15.63 pg/mL - 1000 pg/mL Cell Culture Supernatant, Plasma, Serum
Granzyme B (GZMB) ELISA KitGZMB Reactivity: Human AA 21-247 Colorimetric Sandwich ELISA 15.6-1000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
Granzyme B (GZMB) ELISA KitGZMB Reactivity: Human Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
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- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Expiry Date
- 12 months
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- Target See all GZMB ELISA Kits
- GZMB (Granzyme B (GZMB))
- Alternative Name
- Gzmb (GZMB Products)
- Synonyms
- CCPI ELISA Kit, CGL-1 ELISA Kit, CGL1 ELISA Kit, CSP-B ELISA Kit, CSPB ELISA Kit, CTLA1 ELISA Kit, CTSGL1 ELISA Kit, HLP ELISA Kit, SECT ELISA Kit, granzyme B ELISA Kit, GZMB ELISA Kit
- Background
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Protein Function: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). .
Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Synonyms: Granzyme B(G,H),3.4.21.79,CTLA-1,Cytotoxic cell protease 1,CCP1,Fragmentin-2,Gzmb,Ctla-1, Ctla1,
Full Gene Name: Granzyme B(G,H)
Cellular Localisation: Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells. - UniProt
- P04187
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis
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