Epiregulin ELISA Kit

Catalog No. ABIN5510631

Monkey Epiregulin ELISA Kit Colorimetric assay for quantification of Monkey Epiregulin.

Quick Overview for Epiregulin ELISA Kit (ABIN5510631)

Target: Epiregulin (EREG)

Binding Specificity: AA 60-108

Reactivity: Monkey

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details Epiregulin ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of monkey primate Epiregulin

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: E.coli, V60-L108

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for Epiregulin

Target: Epiregulin (EREG)

Alternative Name: EREG

Background:

Protein Function: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). .

Background: Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. It is a member of the epidermal growth factor family. Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.

Synonyms: Proepiregulin,Epiregulin,EPR,EREG,

Full Gene Name: Proepiregulin

Cellular Localisation: Epiregulin: Secreted, extracellular space.

UniProt: O14944

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation