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Epiregulin ELISA Kit

EREG Reactivity: Pig AA 60-108 Colorimetric Sandwich ELISA
Catalog No. ABIN5510630
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    Epiregulin (EREG)
    Binding Specificity
    AA 60-108
    Reactivity
    • 5
    • 5
    • 1
    • 1
    Pig
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Pig porcine Epiregulin
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    E.coli, V60-L108
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Characteristics

    Tissue Specificity: In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. .

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  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all Epiregulin (EREG) ELISA Kits
    Epiregulin (EREG)
    Alternative Name
    EREG (EREG Products)
    Synonyms
    EREG ELISA Kit, ER ELISA Kit, EPR ELISA Kit, proepiregulin ELISA Kit, epiregulin ELISA Kit, EREG ELISA Kit, ereg ELISA Kit, Ereg ELISA Kit
    Background

    Protein Function: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). .

    Background: Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. It is a member of the epidermal growth factor family. Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.

    Synonyms: Proepiregulin,Epiregulin,EPR,EREG,

    Full Gene Name: Proepiregulin

    Cellular Localisation: Epiregulin: Secreted, extracellular space.
    UniProt
    O14944
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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