Klotho beta ELISA Kit
Quick Overview for Klotho beta ELISA Kit (ABIN5510659)
Target
See all Klotho beta (KLB) ELISA KitsBinding Specificity
Reactivity
Detection Method
Method Type
Application
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Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Klotho beta
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Brand
- PicoKine™
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Analytical Method
- Quantitative
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Specificity
- Expression system for standard: NSO, Immunogen sequence: F53-L997
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Cross-Reactivity (Details)
- There is no detectable cross-reactivity with other relevant proteins.
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Klotho beta (KLB) ELISA Kit
KLB Reactivity: Mouse Colorimetric Sandwich ELISA 15.62 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Klotho beta (KLB) ELISA KitKLB Reactivity: Human Colorimetric Sandwich ELISA 78 pg/mL - 5000 pg/mL Plasma, Serum
Klotho beta (KLB) ELISA KitKLB Reactivity: Human Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Klotho beta (KLB) ELISA KitKLB Reactivity: Human Colorimetric Sandwich ELISA 62.5 pg/mL - 4000 pg/mL Cell Lysate, Plasma, Serum, Tissue Homogenate
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Plate
- Pre-coated
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Restrictions
- For Research Use only
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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Expiry Date
- 12 months
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- Klotho beta (KLB)
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Alternative Name
- KLB
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Background
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Protein Function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). .
Background: Klotho beta, a divergent structural member of the glycosidase I superfamily, is expressed primarily in the liver and pancreas, with lower expression in adipose tissue. It is mapped to chromosome 4. The Klotho beta mediated interaction of human FGF19 (mouse FGF15) with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes, cholesterol 7-alpha hydroxylase (Cyp7a1) and sterol 12-alpha hydroxylase (Cyp8b1). Klotho beta is also an essential cofactor for FGF21 activity and the Klotho gene family may have evolved to confer tissue-specific bioactivity on FGF19 subfamily members.
Synonyms: Beta-klotho,BKL,BetaKlotho,Klotho beta-like protein,KLB,
Full Gene Name: Beta-klotho
Cellular Localisation: Cell membrane, Single-pass type III membrane protein. -
UniProt
- Q86Z14
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Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding
Target See all Klotho beta (KLB) ELISA Kits
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