RSPO1 ELISA Kit

Catalog No. ABIN5510684

Product Details RSPO1 ELISA Kit

Target: RSPO1 (R-Spondin 1 (RSPO1))

Binding Specificity: AA 21-263

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-1

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: S21-A263

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for RSPO1

Target: RSPO1 (R-Spondin 1 (RSPO1))

Alternative Name: RSPO1 (RSPO1 Products)

Synonyms: RGD1565558 ELISA Kit, CRISTIN3 ELISA Kit, RSPO ELISA Kit, R-spondin ELISA Kit, Rspondin ELISA Kit, wu:fj81e05 ELISA Kit, zgc:92153 ELISA Kit, R-spondin 1 ELISA Kit, Rspo1 ELISA Kit, RSPO1 ELISA Kit, LOC100049655 ELISA Kit, rspo1 ELISA Kit

Background:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .

Background: R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene. It is mapped to chromosome 1p34. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy- induced adverse effects. Alternative splicing results in multiple transcript variants.

Synonyms: R-spondin-1,Roof plate-specific spondin-1,hRspo1,RSPO1,

Full Gene Name: R-spondin-1

Cellular Localisation: Secreted . Nucleus . Seems to mainly localize to nucleoli..

UniProt: Q2MKA7