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LDLR ELISA Kit

LDLR Reactivity: Human AA 22-788 Colorimetric Sandwich ELISA
Catalog No. ABIN5510704
$369.00
Plus shipping costs $45.00
96 tests
Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target See all LDLR ELISA Kits
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Binding Specificity
    AA 22-788
    Reactivity
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human LDLR
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO
    Immunogen sequence: A22-R788
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Featured
    Discover our best selling LDLR ELISA Kit
  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all LDLR ELISA Kits
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Alternative Name
    LDLR (LDLR Products)
    Synonyms
    FH, FHC, LDLCQ2, Hlb301, LDLRA, LDLA, low density lipoprotein receptor a, low density lipoprotein receptor, ldlra, LDLR, Ldlr
    Background

    Protein Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

    Background: The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

    Synonyms: Low-density lipoprotein receptor,LDL receptor,LDLR,

    Full Gene Name: Low-density lipoprotein receptor

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein. Endomembrane system, Single-pass type I membrane protein. Membrane, clathrin-coated pit, Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
    UniProt
    P01130
    Pathways
    Hepatitis C, Lipid Metabolism
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