DLL4 ELISA Kit

Catalog No. ABIN5510727

Rat DLL4 ELISA Kit Colorimetric assay for quantification of Rat DLL4.

Quick Overview for DLL4 ELISA Kit (ABIN5510727)

Target: DLL4 (delta-Like 4 (DLL4))

Binding Specificity: AA 28-519

Reactivity: Rat

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details DLL4 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat DLL4

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: S28-E519

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: Dll4

Background:

Protein Function: Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4 (PubMed:25700513). Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity). .

Background: Delta like ligand 4 is a protein that in humans is encoded by the DLL4 gene. It is mapped to 15q15.1. This gene is a homolog of the Drosophila delta gene. DLL4 is a transmembrane ligand for Notch receptors that shows restricted expression to endothelial cells (ECs), in particular to arteries and capillaries, and is involved in vascular development, and it also appeared to be a major trigger of Notch receptor activities previously implicated in arterial and vascular development. DLL4 acts as a negative regulator of tumor angiogenesis, its blockade results in the striking uncoupling of tumor growth from vessel density, presenting a novel therapeutic approach even for tumors resistant to anti-VEGF therapies. In addition to it, this gene also plays an important role in promoting Th17 effector activity during mycobacterial challenge.

Synonyms: Delta-like protein 4 ,Drosophila Delta homolog 4 ,Delta4 ,Dll4 ,

Full Gene Name: Delta-like protein 4

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: D3ZHH1

Pathways: Notch Signaling