Angiopoietin 2 ELISA Kit

Catalog No. ABIN5510731

This Colorimetric ELISA kit is designed for the quantitative measurement of Rat Angiopoietin 2. There are 2 publications available.

Quick Overview for Angiopoietin 2 ELISA Kit (ABIN5510731)

Target: Angiopoietin 2 (ANGPT2)

Binding Specificity: AA 19-496

Reactivity: Rat

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Product Details Angiopoietin 2 ELISA Kit

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Angiopoietin-2

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: Y19-F496

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

References for Angiopoietin 2 ELISA Kit (ABIN5510731)

Cai, Zhang, Huang, Sun, Qiu: "Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 924-932, (2018) (PubMed).

Hu, Wang, Ren, Liu: "Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 200, (2017) (PubMed).

Target Details for Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Alternative Name: Angpt2

Background:

Protein Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). .

Background: Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. ANGPT2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. Its expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

Synonyms: Angiopoietin-2,ANG-2,Angpt2,Agpt2,

Full Gene Name: Angiopoietin-2

Cellular Localisation: Secreted.

UniProt: O35462

Pathways: RTK Signaling