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ICOS ELISA Kit

ICOS Reactivity: Human AA 21-141 Colorimetric Sandwich ELISA 62.5 pg/mL - 4000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
Catalog No. ABIN5692214
  • Target See all ICOS ELISA Kits
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Binding Specificity
    AA 21-141
    Reactivity
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Detection Range
    62.5 pg/mL - 4000 pg/mL
    Minimum Detection Limit
    62.5 pg/mL
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human ICOS. 96wells/kit, with removable strips.
    Brand
    PicoKine™
    Sample Type
    Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO, Immunogen sequence: E21-F141
    Sensitivity
    < 2 pg/mL
    Components
    96-well plate precoated with antibody
    lyophilized recombinant standard
    biotinylated antibody (dilution 1:100)
    Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
    Sample diluent buffer
    Antibody diluent buffer
    ABC diluent buffer
    TMB color developing agent
    TMB stop solution
    Adhesive cover
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  • Assay Time
    15 min
    Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all ICOS ELISA Kits
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Alternative Name
    ICOS (ICOS Products)
    Synonyms
    ICOS ELISA Kit, AILIM ELISA Kit, CCLP ELISA Kit, CRP-1 ELISA Kit, H4 ELISA Kit, Ly115 ELISA Kit, CD278 ELISA Kit, CVID1 ELISA Kit, Ailim ELISA Kit, inducible T-cell costimulator ELISA Kit, inducible T cell co-stimulator ELISA Kit, inducible T-cell co-stimulator ELISA Kit, ICOS ELISA Kit, LOC100232284 ELISA Kit, Icos ELISA Kit
    Background

    Synonyms: Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM

    Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

    Background: Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

    Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.
    UniProt
    Q9Y6W8
    Pathways
    Cancer Immune Checkpoints
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