PRTN3 ELISA Kit
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- Target See all PRTN3 ELISA Kits
- PRTN3 (Proteinase 3 (PRTN3))
- Detection Method
- Colorimetric
- Method Type
- Competition ELISA
- Application
- ELISA
- Purpose
- Proteinase-3 (PR-3) Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of antibodies to PR-3 in human sera. The assay is to be used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid in the diagnosis of Wegener’s granulomatosis
- Analytical Method
- Semi-Quantitative
- Specificity
- 95.6%
- Sensitivity
- 98.2%
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- Discover our best selling PRTN3 ELISA Kit
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- Discover our top product PRTN3 ELISA Kit
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Proteinase 3 (PRTN3) ELISA Kit
PRTN3 Reactivity: Human Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum
Proteinase 3 (PRTN3) ELISA KitPRTN3 Reactivity: Human Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Plasma, Serum, Tissue Homogenate, Urine
Proteinase 3 (PRTN3) ELISA KitPRTN3 Reactivity: Human Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Proteinase 3 (PRTN3) ELISA KitPRTN3 Reactivity: Human Colorimetric Sandwich ELISA 0.16 ng/mL - 10 ng/mL Cell Culture Supernatant, Plasma, Serum
Proteinase 3 (PRTN3) ELISA KitPRTN3 Reactivity: Mouse Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Proteinase 3 (PRTN3) ELISA KitPRTN3 Reactivity: Rat Colorimetric Sandwich ELISA 3.12 ng/mL - 200 ng/mL Plasma, Serum
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- Sample Volume
- 10 μL
- Assay Time
- 1 - 2 h
- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C
- Expiry Date
- 12 months
-
- Target See all PRTN3 ELISA Kits
- PRTN3 (Proteinase 3 (PRTN3))
- Alternative Name
- PR3 (c-ANCA) (PRTN3 Products)
- Synonyms
- ela2 ELISA Kit, MGC132250 ELISA Kit, ACPA ELISA Kit, AGP7 ELISA Kit, C-ANCA ELISA Kit, CANCA ELISA Kit, MBN ELISA Kit, MBT ELISA Kit, NP-4 ELISA Kit, NP4 ELISA Kit, P29 ELISA Kit, PR-3 ELISA Kit, PR3 ELISA Kit, mPR3 ELISA Kit, proteinase 3 L homeolog ELISA Kit, proteinase 3 ELISA Kit, prtn3.L ELISA Kit, PRTN3 ELISA Kit, Prtn3 ELISA Kit
- Background
- Proteinase-3 is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c- ANCA and p-ANCA. The first subtype, c-ANCA, shows cytoplasmic staining by IFA and is diagnostic for Wegener's granulomatosis. The major antigen responsible for the c-ANCA staining is Proteinase-3. The second subtype, p-ANCA, shows perinuclear staining by IFA. The major antigen responsible for the p-ANCA response has been shown to be myeloperoxidase. The ANCA staining patterns are obtained using ethanol-fixed human neutrophils. Anti- PR-3 autoantibodies have been associated with Wegener's granulomatosis but less often with microscopic polyangiitis. Other antigen specificity's (CAP 57) can be responsible for the c-ANCA pattern. These antigens are generally not diagnostic for PR-3 associated vaculitus diseases.
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