MUC1 ELISA Kit

Catalog No. ABIN996900

The MUC1 ELISA Kit (ABIN996900) is a Colorimetric ELISA Kit designed to quantify MUC1.

Quick Overview for MUC1 ELISA Kit (ABIN996900)

Target: MUC1 (Mucin 1 (MUC1))

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Detection Range: 0-200 U/mL

Application: ELISA

Sample Type: Serum

Product Details MUC1 ELISA Kit

Minimum Detection Limit: 0 U/mL

Purpose: Enzyme Immunoassay for the Quantitative Measurement of Breast Cancer Antigen (CA15-3) in Human Serum.

Analytical Method: Quantitative

Specificity: 97 %

Sensitivity: 5 U/mL

Application Details

Sample Volume: 20 μL

Assay Time: 2 - 3 h

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C

Expiry Date: 12-14 months

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: CA15-3

Background: Breast cancer is the most common life-threatening malignant lesion in women of many developed countries today, with approximately 180,000 new cases diagnosed every year. Roughly half of these newly diagnosed patients are node-negative, however 30% of these cases progress to metastatic disease. here are a number of tumor markers that can help clinicians to identify and diagnose which breast cancer patients will have aggressive disease and which will have an indolent course. These markers include estrogen and progesterone receptors, DNA ploidy and percent-S phase profile, epidermal growth factor receptor, HER-2/neu oncogene, p53 tumor suppressor gene, cathepsin D, proliferation markers and CA15-3.

CA15-3 is most useful for monitoring patients post-operatively for recurrence, particularly metastatic diseases. 96% of patients with local and systemic recurrence have elevated CA15-3, which can be used to predict recurrence earlier than radiological and clinical criteria. A 25% increase in the serum CA15-3 is associated with progression of carcinoma. A 50% decrease in serum CA15-3 is associated with response to treatment. CA15-3 are more sensitive than CEA in early detection of breast cancer recurrence. In combination with CA-125, CA15-3 has been shown to be useful in early detection of relapse of ovarian cancer. CA15-3 levels are also increased in colon, lung and hepatic tumors.

Pathways: Negative Regulation of intrinsic apoptotic Signaling