KPNB1 Products
(Karyopherin (Importin) beta 1 (KPNB1))
Categories
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
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Featured KPNB1 Categories
KPNB1 Antibodies
High quality antibodies with extensive validation data.
KPNB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
KPNB1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KPNB1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, FACS, IF
Validations
- (5)
Cat. No.
ABIN185516
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6142997
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
Cat. No.
ABIN390792
Quantity
400 μL
Datasheet
Datasheet
Recommended KPNB1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957266
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5656173
Quantity
96 tests
Datasheet
Datasheet
Recommended KPNB1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308928
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3093074
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3134614
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KPNB1 products
: "Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import." in: Science advances, Vol. 5, Issue 10, pp. eaaw7373, (2019) (PubMed).: "Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 46, pp. 16502-7, (2014) (PubMed).
: "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1." in: The Journal of biological chemistry, Vol. 281, Issue 30, pp. 20883-90, (2006) (PubMed).
: "Spatial coordination of spindle assembly by chromosome-mediated signaling gradients." in: Science (New York, N.Y.), Vol. 309, Issue 5739, pp. 1373-6, (2005) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "Exercise training attenuates coronary smooth muscle phenotypic modulation and nuclear Ca2+ signaling." in: American journal of physiology. Heart and circulatory physiology, Vol. 283, Issue 6, pp. H2397-410, (2002) (PubMed).
: "Role of importin-beta in coupling Ran to downstream targets in microtubule assembly." in: Science (New York, N.Y.), Vol. 291, Issue 5504, pp. 653-6, (2001) (PubMed).
: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).
: "Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins." in: Cell, Vol. 83, Issue 5, pp. 683-92, (1996) (PubMed).
: "Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1769-73, (1995) (PubMed).
Synonyms and alternative names related to KPNB1
importin beta-1 subunit (AFUA_1G15720), importin beta-1 subunit (AOR_1_1974174), Importin beta-1 subunit (Bm1_57540), importin beta-1 subunit (PMAA_065830), importin beta-1 subunit (AFLA_083750), importin beta-1 subunit (TSTA_085870), importin beta-1 subunit (BDBG_07509), importin beta-1 subunit (MCYG_00039), karyopherin (importin) beta 1 L homeolog (kpnb1.L), importin beta 1 (LOC100533387), karyopherin subunit beta 1 (KPNB1), karyopherin (importin) beta 1 (Kpnb1), karyopherin subunit beta 1 (Kpnb1), AA409963, Afu1g15720, AO090005001133, imb1, IMB1, impnb, Impnb, ipo1, IPO1, ipob, IPOB, ntf97, NTF97Protein level used designations for KPNB1
- Importin beta-1 subunit
- importin beta-1 subunit
- importin beta 1
- PTAC97
- importin 1
- importin 90
- importin subunit beta-1
- importin-90
- karyopherin subunit beta-1
- nuclear factor p97
- pore targeting complex 97 kDa subunit
- SCG
- importin beta
- Importin beta
- karyopherin,beta 1
- nuclear factor P97
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