Lipin 1 Products
(Lipin 1 (LPIN1))
Categories
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012].
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Featured Lipin 1 Categories
Lipin 1 Antibodies
High quality antibodies with extensive validation data.
Lipin 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Lipin 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Lipin 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7436306
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
- (2)
Cat. No.
ABIN540690
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7163118
Quantity
100 μL
Datasheet
Datasheet
Recommended Lipin 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957497
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957498
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957499
Quantity
96 tests
Datasheet
Datasheet
Recommended Lipin 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309703
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309702
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3093621
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Lipin 1 products
: "C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10214-29, (2013) (PubMed).: "Expression of cyclins-B and cyclins-e in individual molt-4 cells and in stimulated human-lymphocytes during their progression through the cell-cycle." in: International journal of oncology, Vol. 3, Issue 6, pp. 1037-42, (2011) (PubMed).
: "Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38035-42, (2011) (PubMed).
: "Subcellular localization and role of lipin-1 in human macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 10, pp. 6004-13, (2011) (PubMed).
: "Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 19, pp. 14628-38, (2010) (PubMed).
: "Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism." in: Human molecular genetics, Vol. 15, Issue 3, pp. 377-86, (2006) (PubMed).
: "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway." in: Cell metabolism, Vol. 4, Issue 3, pp. 199-210, (2006) (PubMed).
: "The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9210-8, (2006) (PubMed).
: "Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis." in: The Journal of biological chemistry, Vol. 280, Issue 38, pp. 32883-9, (2005) (PubMed).
: "Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 1047-52, (2002) (PubMed).
Synonyms and alternative names related to Lipin 1
lipin 1 (LPIN1), lipin 1 (lpin1), phosphatidate phosphatase LPIN1 (LOC100539289), lipin 1 (Lpin1), 4631420P06, fld, Kiaa0188, Lipin1, lipin1, LPIN1, mKIAA0188, pap1, PAP1, zgc:194552, zgc:194558Protein level used designations for Lipin 1
- lipin 1
- phosphatidate phosphatase LPIN1-like
- lipin-1
- phosphatidate phosphatase LPIN1
- fatty liver dystrophy protein
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