LITAF Products
(Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))
Categories
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].
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Featured LITAF Categories
LITAF Antibodies
High quality antibodies with extensive validation data.
LITAF ELISA Kits
Reliable ELISA kits for a wide range of species.
LITAF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LITAF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN523000
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7074508
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7158438
Quantity
100 μL
Datasheet
Datasheet
Recommended LITAF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Chicken
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5593872
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1140821
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1140824
Quantity
96 tests
Datasheet
Datasheet
Recommended LITAF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123779
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098763
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309476
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our LITAF products
: "Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes." in: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1619-37, S1-3, (2013) (PubMed).: "LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 37, pp. 13777-82, (2006) (PubMed).
: "SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation." in: Human mutation, Vol. 25, Issue 4, pp. 372-83, (2005) (PubMed).
: "Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 23065-76, (2001) (PubMed).
: "A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4518-23, (1999) (PubMed).
Synonyms and alternative names related to LITAF
lipopolysaccharide induced TNF factor (LITAF), lipopolysaccharide-induced TNF factor (Litaf), LPS-induced TN factor (Litaf), 3222402J11Rik, C85531, EET-1, N4WBP3, PIG7, Pig7, SIMPLE, TBX1, TNF-alpha, TP53I7Protein level used designations for LITAF
- LPS-induced TNF-alpha factor
- lipopolysaccharide-induced TNF-alpha factor
- lipopolysaccharide-induced tumor necrosis factor-alpha factor
- p53-induced gene 7 protein
- small integral membrane protein of lysosome/late endosome
- tumor protein p53 inducible protein 7
- LPS-induced TN factor
- LPS-induced TNF-alpha factor homolog
- estrogen-enhanced transcript protein 1
- estrogen-responsive uterine transcript
- lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
- TNF-alpha factor
- lipid-induced TNF-alpha factor
- tissue necrosis factor-alpha
- LITAF-like protein
- Nedd4 WW domain-binding protein 3
- estrogen-enhanced transcript protein
- mEET
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