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Human Monoclonal PPP1CB Primary Antibody for WB - ABIN534430
Gao, Zhou, Xie, Zhang, Rahmeh, Huang, Lee, Lee: Protein phosphatase-1 is targeted to DNA polymerase delta via an interaction with the p68 subunit. in Biochemistry 2008
Show all 2 Pubmed References
PPP1CB mutation is associated with Noonan syndrome.
This report gives further support that this novel RASopathy-PPP1CB-related Noonan syndrome with loose anagen hair-shares great similarity to Noonan syndrome-like disorder with loose anagen hair, and expands the phenotypic spectrum by adding the cranial vault abnormality.
Missense mutations in PPP1CB are associated with a phenotype resembling NS-LAH. Based on this phenotype and PPP1CB's known role within the RAS/MAPK pathway, we think that this condition is a novel rasopathy, which may be provisionally termed "PPP1CB-related Noonan syndrome with loose anagen hair" (P-NS-LAH).
this study shows a pivotal role for PP1 in impeding IRF7-mediated IFN-alpha production in host immune responses
Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability.
These results suggest a unique functional role for the PP1beta isoform in affecting cardiac contractile function
Findings show that PP1cbeta plays a role in endothelial cell migration through a mechanism involving the interplay of actin cytoskeleton proteins and focal adhesion molecules signaling.
PPP1C isoforms have distinct contribution to the outside-in alphaIIbbeta3 signalling-dependent functions in HEK293 alphaIIbbeta3 cells.
results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation
Studies suggest that any change in substrate specificity of the spinophilin : PP1 holoenzyme complex was probably due to direct modification of a PP1 substrate binding surface.
Studies indicate that the diversity of the PP1 interactome and the properties of the PP1 binding code account for the exquisite specificity of PP1 in vivo.
Studies indicate that the Ser/Thr phosphatases PP1 and PP2A are responsible for the dephosphorylation and activation of Rb proteins.
Interaction between protein phosphatase 1 beta and myosin phosphatase (MYPT)1 results in exclusion of Nkx2.5 from the cell nucleus.
These findings provide evidence for the involvement of a particular PP1 complex, PPP1R12A/PP1cdelta, in insulin signaling.
Protein phosphatase 1beta (PP1beta) is identified as a phosphatase for the cluster of phosphorylated threonines ((353)TTETQRT(359)) within the sst(2A) somatostatin receptor carboxyl terminus that mediates beta-arrestin binding using siRNA knock-down screening.
PPP1CB is over expressed in malignant melanoma.
Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.
serine/threonine protein phosphatase PP1beta is a physiological Nucleophosmin (NPM) phosphatase under both the genotoxic stress and growth conditions.
PP-1 ( PP-1alpha or PP-1beta ) acts as a major phosphatase to dephosphorylate AKT1 at Thr-450 and thus modulate its functions in regulating gene expression, cell survival and differentiation.
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
Smooth muscle-specific conditional PP1cbeta knockout decreased contractile force development in bladder, ileal, and aortic tissues and reduced mouse survival.
PPP1CB is a novel adipogenic activator that promotes adipogenesis in vivo and in vitro.
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo.
the phosphatase PPM1B as a novel selective modulator of PPARgamma activity.
Although a non-myristoylated mutation (G2A) of PPM1A and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha.
These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development.
PP-1 is more abundant than PP-2A in the mouse eye; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-Balpha/beta/gamma are all differentially expressed.
cloning and expression profile of PPP1CB; part of the genomic sequence and polymorphisms were cloned and characterized
zebrafish have two genes encoding PP1beta, both of which can interact with Mypt1
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
protein phosphatase 1, catalytic subunit, beta isoform
, protein phosphatase 1, catalytic subunit, delta isoform
, protein phosphatase 1-beta
, protein phosphatase 1-delta
, serine/threonine protein phosphatase PP1-beta catalytic subunit
, serine/threonine-protein phosphatase PP1-beta catalytic subunit
, protein phosphatase 1, catalytic subunit,, delta (gizzard)
, protein phosphatase-1 delta
, protein phosphatase type 1 beta isoform
, protein phosphatase type 1 catalytic subunit delta isoform
, protein phosphatase 1B
, protein phosphatase 2C isoform beta
, protein phosphatase-1a