MAGI (PDZ 4-5) antibody
This Sheep Polyclonal antibody specifically detects MAGI (PDZ 4-5) in WB. It exhibits reactivity toward Human.
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Catalog No. ABIN306589
$368.50
Plus shipping costs $50.00
250 μg
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United States
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Quick Overview for MAGI (PDZ 4-5) antibody (ABIN306589)
Target
MAGI (PDZ 4-5) (MAGI)
(Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))
Reactivity
Human
Host
Sheep
Clonality
Polyclonal
Application
Western Blotting (WB)
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Purpose
- Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI)
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Characteristics
- Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.
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Purification
- Ammonium Sulfate Precipitation
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Immunogen
- Recombinant protein corresponding to PDZ domains 4-5 of MAGI-3.
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Isotype
- IgG
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Application Notes
- Antibody detects MAGI-3 by Western blot at 1-10 μg/mL. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/ml
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Buffer
- phosphate buffered saline with 0.08 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- MAGI (PDZ 4-5) (MAGI) (Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))
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Background
- Sheep anti-Membrane-associated guanylate cyclase of inverted orientation-3, PSD95 DiscsLarge Z01 domains 4-5
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UniProt
- Q9H2V6
Target
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