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anti-Rat (Rattus) SGOL1 Antibodies:
anti-Human SGOL1 Antibodies:
anti-Mouse (Murine) SGOL1 Antibodies:
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Human Monoclonal SGOL1 Primary Antibody for IP, ELISA - ABIN566873
Dai, Sullivan, Higgins: Regulation of mitotic chromosome cohesion by Haspin and Aurora B. in Developmental cell 2006
Show all 9 Pubmed References
Polyclonal SGOL1 Primary Antibody for WB - ABIN540303
Nobumori, Shouse, Wu, Lee, Shen, Liu: B56? tumor-associated mutations provide new mechanisms for B56?-PP2A tumor suppressor activity. in Molecular cancer research : MCR 2013
Molecular chaperone (show HSP90AA1 Antibodies) SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Aurora B kinase (show AURKB Antibodies) interacts with and phosphorylates Sgo1. Aurora B (show AURKB Antibodies)-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms.
SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.
Cohesin complex (show SMC3 Antibodies) is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A (show PPP2R4 Antibodies) recruitment.
Sgo1 co-recruits Aurora B (show AURKB Antibodies) and PP2A (show PPP2R4 Antibodies) to centromeres of unattached chromosomes.
Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
our findings strongly suggest that CIP2A (show KIAA1524 Antibodies) promotes cell cycle progression, premature chromosome segregation, and aneuploidy, possibly through a novel interaction with Sgol1.
Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription.
Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut (show GUSB Antibodies) rhythm.
Bub1 (show BUB1 Antibodies)-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation.
MYCN (show MYCN Antibodies)-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN (show MYCN Antibodies)- or MYC (show MYC Antibodies)-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase.
Study shows Sgo1 expression in heart, gut (show GUSB Antibodies), eye and other central nervous system tissue during development and post-development. It demonstrates Sgo1 localization in cytoplasmic region in nucleated cells in select organs.
Data show that compound mutant spindle assembly checkpoint components BubR1 (show BUB1B Antibodies) and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development.
Sgo1(-/+)-mediated ME-CIN (show PDXP Antibodies) strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself.
Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells.
It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1 (show BUB1 Antibodies)-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1.
report structure and function of the PP2A (show PPP2R2B Antibodies)-shugoshin interaction.
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
, shugoshin-like protein
, shugosin centromeric cohesion1
, serologically defined breast cancer antigen NY-BR-85
, shugoshin 1AB protein
, shugoshin 1CD protein
, shugoshin 1EF protein
, shugoshin 1GH protein
, shugoshin 1KL protein
, shugoshin-like 1
, shugoshin 1A protein