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anti-Rat (Rattus) SGOL1 Antibodies:
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Human Monoclonal SGOL1 Primary Antibody for IP, ELISA - ABIN566873
Dai, Sullivan, Higgins: Regulation of mitotic chromosome cohesion by Haspin and Aurora B. in Developmental cell 2006
Show all 9 Pubmed References
Schizosaccharomyces pombe Polyclonal SGOL1 Primary Antibody for IF, WB - ABIN2452123
Watanabe, Kitajima: Shugoshin protects cohesin complexes at centromeres. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005
Show all 3 Pubmed References
Polyclonal SGOL1 Primary Antibody for WB - ABIN540303
Nobumori, Shouse, Wu, Lee, Shen, Liu: B56? tumor-associated mutations provide new mechanisms for B56?-PP2A tumor suppressor activity. in Molecular cancer research : MCR 2013
Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process.
A major function of RSF1 is to recruit HDAC1 to centromeres, where it antagonizes Tip60-mediated acetylation of H2A- K118, which allows Sgo1 accumulation and centromeric cohesion protection.
Many factors involved in the chromatin association of Shugoshin proteins are well established, most strikingly through modifications found directly on centromeric and pericentric chromatin. It has been well established that phosphorylation at the centromere is essential to nucleating Shugoshin recruitment.
Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Aurora B kinase interacts with and phosphorylates Sgo1. Aurora B-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms.
SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.
Cohesin complex is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A recruitment.
Sgo1 co-recruits Aurora B and PP2A to centromeres of unattached chromosomes.
Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC).
our findings strongly suggest that CIP2A promotes cell cycle progression, premature chromosome segregation, and aneuploidy, possibly through a novel interaction with Sgol1.
Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription.
Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm.
Bub1-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation.
The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3.
Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.
SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance
Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth
These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability.
HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export.
MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase.
Study shows Sgo1 expression in heart, gut, eye and other central nervous system tissue during development and post-development. It demonstrates Sgo1 localization in cytoplasmic region in nucleated cells in select organs.
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development.
Sgo1(-/+)-mediated ME-CIN strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself.
Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells.
It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1.
report structure and function of the PP2A-shugoshin interaction.
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
, shugoshin-like protein
, shugosin centromeric cohesion1
, serologically defined breast cancer antigen NY-BR-85
, shugoshin 1AB protein
, shugoshin 1CD protein
, shugoshin 1EF protein
, shugoshin 1GH protein
, shugoshin 1KL protein
, shugoshin-like 1
, shugoshin 1A protein