Browse our anti-MAP2K5 (MAP2K5) Antibodies

Human Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. When yeast genetic interaction partners held in common between human OPTN (show OPTN Antibodies) and ANG (show ANG Antibodies) were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy

2. For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 (show MAPK7 Antibodies) shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5 (show MAPK7 Antibodies)). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 (show MAPK7 Antibodies) is an essential mediator of this process. Therefore, ERK5 (show MAPK7 Antibodies) may be a potential therapeutic target for promoting angiogenesis

3. results confirmed the association of BTBD9 (show BTBD9 Antibodies) and MAP2K5/SKOR1 (show SKOR1 Antibodies) with primary Restless Legs Syndrome in Chinese population

4. Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.

5. Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (show STAT3 Antibodies) augments breast cancer cell EMT (show ITK Antibodies), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (show STAT3 Antibodies) and MEK5/Erk5 (show MAPK7 Antibodies) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.

6. Our findings confirm an association between the BTBD9 (show BTBD9 Antibodies), MEIS1 (show MEIS1 Antibodies), and MAP2K5/SKOR1 (show SKOR1 Antibodies) SNPs and periodic limb movements of sleep in an elderly cohort.

7. Specifically, CKS1B (show CKS1B Antibodies) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (show PACSIN1 Antibodies), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.

8. High MEK5 expression is associated with colorectal cancer.

9. SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.

10. Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (show BTBD9 Antibodies), TOX3 (show TOX3 Antibodies)/BC034767, MEIS1 (show MEIS1 Antibodies), MAP2K5/SKOR1 (show SKOR1 Antibodies), and PTPRD (show PTPRD Antibodies)

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. These results suggest that YAP (show YAP1 Antibodies) promotes muscle differentiation by activating the Abl (show ABL1 Antibodies)/Src (show SRC Antibodies)/MEKK3 (show MAP3K3 Antibodies)/MEK5/ERK5 (show MAPK7 Antibodies) kinase cascade.

2. MEK5 overexpression inhibits differentiation of osteoblasts.

3. the MEK5-ERK5 (show MAPK7 Antibodies) MAP kinase (show MAPK1 Antibodies) signaling pathway has a critical role in BAFF (show TNFSF13B Antibodies)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers

4. The MEK5/ERK5 (show MAPK7 Antibodies) pathway also mediates FSS-induced Runx-2 (show RUNX2 Antibodies) expression in osteoblast differentiation.

5. finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression

6. PB1 (show GPR97 Antibodies) domain mediates the association of MEKK2 (show MAP3K2 Antibodies) and MEKK3 (show MAP3K3 Antibodies) with MEK5 and that the respective PB1 (show GPR97 Antibodies) domains of these kinases are critical for regulation of the ERK5 (show MAPK7 Antibodies) pathway.

7. MEK5 is an activator of ERK5 (show MAPK7 Antibodies) and an essential regulator of cell survival that is required for normal embryonic development

8. the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (show MAPK7 Antibodies) signaling pathway

9. MEK5 and big MAP kinase 1 (BMK1 (show MAPK7 Antibodies)) function downstream of MEKK3 (show MAP3K3 Antibodies) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (show PPP3R1 Antibodies)

10. A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (show MAPK7 Antibodies) kinase and map2k7 (show MAP2K7 Antibodies) signaling.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. The Arabidopsis MKK4 (show MAP2K4 Antibodies)/MKK5-MPK6 (show MAPK6 Antibodies) cascade is an important player in the maternal control of embryogenesis.

2. results indicated that AIK1-MKK5-MPK6 (show MAPK6 Antibodies) functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (show MAPK1 Antibodies) cascade.

3. AIK1-MKK5-MPK6 (show MAPK6 Antibodies) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.

4. MKK4 (show MAP2K4 Antibodies), MKK5, MKK7 (show MAP2K7 Antibodies), and MKK9, are responsible for the activation of MPK3 (show MAPK3 Antibodies) and MPK6 (show MAPK6 Antibodies) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Antibodies) signaling through MKK4 (show MAP2K4 Antibodies)/5/7/9-MPK3 (show MAPK3 Antibodies)/6 cascades.

5. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (show MAPK6 Antibodies), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.

6. our data indicate that EDR1 (show PHC1 Antibodies) physically associates with MKK4 (show MAP2K4 Antibodies)/MKK5 and negatively regulates the MAPK (show MAPK1 Antibodies) cascade to fine-tune plant innate immunity.

7. Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (show TGFB1 Antibodies) as well as the activation of MKK5 activity were completely arrested.

8. Results suggest that the YDA-MKK4 (show MAP2K4 Antibodies)/MKK5-MPK3 (show MAPK3 Antibodies)/MPK6 (show MAPK6 Antibodies) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.

9. MKK5 functions both in ozone-induced activation of MPK3 (show MAPK3 Antibodies) and MPK6 (show MAPK6 Antibodies) and in integrating reactive oxygen species homeostasis during ozone stress.

10. MKK5 is a key regulator of stomatal development and patterning.