Browse our anti-MAP2K5 (MAP2K5) Antibodies

Human Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. Study in Chinese familial non-medullary thyroid carcinoma patients revealed that MAP2K5 variants A321T or M367 T can activate MAP2K5-ERK5 pathway, alter downstream gene expression, and subsequently induce thyroid epithelial cell malignant transformation.

2. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy

3. For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 is an essential mediator of this process. Therefore, ERK5 may be a potential therapeutic target for promoting angiogenesis

4. results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population

5. Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.

6. Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 augments breast cancer cell EMT, which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 and MEK5/Erk5 pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.

7. Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort.

8. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.

9. High MEK5 expression is associated with colorectal cancer.

10. SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.

11. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD

12. Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5-ERK5 signaling.

13. MiR-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits

14. MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.

15. Single nucleotide polymorphism in the MAP2K5 gene is associated with BMI and obesity.

16. data indicate that the rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer

17. Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of restless legs syndrome in a United States population.

18. HCVne particles are capable of inducing the recently discovered ERK5 pathway, in a dose dependent way.

19. These results suggest that MEK5/ERK5 is important for FLT3-ITD induced hematopoietic transformation.

20. MEK5 activation by laminar shear stress inhibits inflammatory responses in microvascular endothelial cells, in part through ERK5-dependent induction of KLF4

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. These results suggest that YAP promotes muscle differentiation by activating the Abl/Src/MEKK3/MEK5/ERK5 kinase cascade.

2. MEK5 overexpression inhibits differentiation of osteoblasts.

3. the MEK5-ERK5 MAP kinase signaling pathway has a critical role in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers

4. The MEK5/ERK5 pathway also mediates FSS-induced Runx-2 expression in osteoblast differentiation.

5. finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression

6. PB1 domain mediates the association of MEKK2 and MEKK3 with MEK5 and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 pathway.

7. MEK5 is an activator of ERK5 and an essential regulator of cell survival that is required for normal embryonic development

8. the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 signaling pathway

9. MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1

10. A noncanonical function of Map2k5 domain is decribed for coordinated erk5 kinase and map2k7 signaling.

11. Results show the critical involvement of the MEK5-ERK5 pathway in thymocyte development distinct from that of ERK1/2 and highlight the importance of the MAPK network in mediating differential effects pertaining to T-cell differentiation and apoptosis.

12. Transfection of myoblasts with dominant-negative MEK5 blocked the pro-myogenic action of IGF-2.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) interaction partners

1. The Arabidopsis MKK4/MKK5-MPK6 cascade is an important player in the maternal control of embryogenesis.

2. results indicated that AIK1-MKK5-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK cascade.

3. AIK1-MKK5-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.

4. MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK signaling through MKK4/5/7/9-MPK3/6 cascades.

5. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.

6. our data indicate that EDR1 physically associates with MKK4/MKK5 and negatively regulates the MAPK cascade to fine-tune plant innate immunity.

7. Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested.

8. Results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.

9. MKK5 functions both in ozone-induced activation of MPK3 and MPK6 and in integrating reactive oxygen species homeostasis during ozone stress.

10. MKK5 is a key regulator of stomatal development and patterning.