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anti-Rat (Rattus) MAP2K7 Antibodies:
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Human Monoclonal MAP2K7 Primary Antibody for ICC, FACS - ABIN969271
Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Polyclonal MAP2K7 Primary Antibody for IHC, ELISA - ABIN1847618
Zhang, Wang, Man, Zhu, Bai, Wei, Liu, Liu, Wang, Gu, Wang: Reactive oxygen species generated from skeletal muscles are required for gecko tail regeneration. in Scientific reports 2017
The assessment of the interaction between GADD45beta and MKK7 and the elucidation of the recognition surfaces between DTP3 and MKK7 significantly advance the understanding of the mechanism underlying the inhibition of the GADD45beta/MKK7 interaction by DTP3 and pave the way to the design of small-molecule DTP3 analogues.
In the coBRIM phase III trial, the addition of cobimetinib, an MEK inhibitor, to vemurafenib, a BRAF inhibitor, significantly improved progression-free survival [hazard ratio (HR), 0.58; P < 0.0001] and overall survival (HR, 0.70; P = 0.005) in advanced BRAF-mutated melanoma. Here, we report on the incidence, course, and management of key adverse events (AEs) in the coBRIM study
the p.Glu116Lys rare variant in MAP2K7 predisposes its carriers to develop COPD, which would provide a useful genetic biomarker for COPD susceptibility in Chinese.
Combination BRAF and MEK inhibition has also been shown to improve overall survival in patients with V600E-mutated melanoma. Responses to therapy are often rapid, and treatment is not associated with immune-related adverse events.
Our findings indicate that GADD45 essentially suppresses the MKK7-JNK pathway and suggest that differentially expressed GADD45 family members fine-tune stress-inducible JNK activity.
The latter insight is likely to promote the production of allosteric MAP2K7 inhibitors.
MEK activation cooperates with Cdkn2a and Pten inactivation to induce melanoma
MKK7 undergoes neddylation in human breast cancer cells
In an Eastern Chinese population, carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC.
Therefore, EGF is suggested to induce E-cadherin down-regulation at the transcriptional level through the MEK/ERK pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.
combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers
our study suggested that black rice anthocyanins extract suppress metastasis in breast cancer cells by targeting the RAS/RAF/MAPK pathway
Crystal structures of the wild type and C218S mutant of MAP2K7 were determined. Cys218 plays a crucial role in configuring an auto-inhibition form of MAP2K7.
We found that the MKK7 p.Glu116Lys rare polymorphism was significantly associated with lung cancer risk, progression and prognosis
we explored the effects of selumetinib in combination with gefitinib in a panel of TNBC cells, in order to evaluate whether the simultaneous blockade of the EGFR and the RAS/MEK/ERK pathway might increase the antitumor activity of selumetinib in TNBC.
a widespread role for the JNK-CELF2 axis in controlling splicing during T-cell activation, including a specific role in propagating JNK signaling.
This review will focus on the science and clinical findings related to targeted therapies that inhibit BRAF or MEK as well as the immunotherapies that block the CTLA-4 or PD-1 pathways
BCR-ABL promotes PTEN downregulation through a MEK dependent pathway.
The crystal structure of JNK1 in complex with the second docking site of MKK7, was determined, revealing two different binding modes of the docking motif correlating with observations from NMR exchange spectroscopy.
In conclusion, the expression of hepatitis B virus core protein sensitized hepatocytes to TNF-alpha-induced apoptosis by disrupting the interaction between MKK7 and RACK1.
we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system. MKK7 cKO mice displayed impaired circadian behavioral rhythms and decreased locomotor activity. MKK7 cKO mice at 8 months showed motor dysfunctions such as weakness of hind-limb and gait abnormality in an age-dependent manner.
SENP3 potentiates lipopolysaccharide-induced TLR4 signaling via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation and the downstream events
High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
The loss of mkk4 and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.
Arrestin-3 directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 and MKK7 in vitro as well as in intact cells.
MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation.
Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.
a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4/7 and JNK1/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
This study demonistrated that Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.
The role of NF-kappaB and c-jun N-terminal kinase (JNK) activation in RANKL-induced osteoclast differentiation was investigated using an adenovirus vector carrying the dominant negative 1kappaB kinase 2 gene or dominant negative MKK7 gene.
myocardial MKK7D has a role in significant JNK activation, robust induction of the fetal gene program, and contractile dysfunction
Genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic lethality and impaired proliferation of hepatocytes.
Changes in MKK7 gene expression between subspecies of Mus musculus are most likely affected by positive selection.
Differential employment of MKK4 and MKK7 by scaffold proteins Axin, Dvl, and Epstein-Barr virus latent membrane protein-1 (LMP-1) in mediating JNK activation was examined.
A noncanonical function of Map2k5 and Map3k2 domain is decribed for coordinating erk5 kinase and map2k7 signaling.
These results suggest that HSP70 expression is up-regulated by SEK1 and down-regulated by MKK7 through distinct MAPK isoforms in mouse embryonic stem cells treated with cadmium chloride.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
mitogen-activated protein kinase kinase 7
, JNK kinase 2
, JNK-activating kinase 2
, JNKK 2
, MAP kinase kinase 7
, MAPK/ERK kinase 7
, MAPKK 7
, MEK 7
, c-Jun N-terminal kinase kinase 2
, dual specificity mitogen-activated protein kinase kinase 7
, SAPK kinase 4
, stress-activated protein kinase kinase 4
, mitogen activated protein kinase kinase 7
, protein kinase, mitogen activated, kinase 7