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anti-Human MAPK14 Antibodies:
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Human Polyclonal MAPK14 Primary Antibody for FACS, IF - ABIN1882176
Cheung, Campbell, Nebreda, Cohen: Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. in The EMBO journal 2003
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Chicken Polyclonal MAPK14 Primary Antibody for IHC (fro), WB - ABIN550189
Shi, Gaestel: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. in Biological chemistry 2002
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN3020064
Kumar, Wang, Liu, Ding, Dong, Zheng, Ye, Liu: Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms. in Hypertension (Dallas, Tex. : 1979) 2018
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Mouse (Murine) Polyclonal MAPK14 Primary Antibody for WB - ABIN3023583
Zhang, Xie, Wu, Jin, Liu, Hu, Fu, Ding, Zhang, Cao: Doxycycline Attenuates Leptospira-Induced IL-1β by Suppressing NLRP3 Inflammasome Priming. in Frontiers in immunology 2017
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN6673820
He, Zhao, Anees, Li, Ashraf, Chen, Song, Chen, Cao, Ye: p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes. in Frontiers in cellular and infection microbiology 2018
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN6718996
Yu, Mu, Fan, Lei, Yan, Wang, Tang, Wang, Yu, Zhang: Insulin-like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways. in Histochemistry and cell biology 2012
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN6671645
Dong, Liu, Meng, Liu, Bi, Wu, Jin, Yao, Tang, Wang, Li, Zhang, Yu, Zhan, Chen, Ge, Yang, Li: Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination. in Scientific reports 2018
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN6683125
Oyagbemi, Omobowale, Ochigbo, Asenuga, Ola-Davies, Ajibade, Saba, Adedapo: Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats. in Journal of dietary supplements 2018
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Human Monoclonal MAPK14 Primary Antibody for WB - ABIN532630
Herlaar, Brown: p38 MAPK signalling cascades in inflammatory disease. in Molecular medicine today 1999
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Human Polyclonal MAPK14 Primary Antibody for WB - ABIN540787
Martín-Blanco: p38 MAPK signalling cascades: ancient roles and new functions. in BioEssays : news and reviews in molecular, cellular and developmental biology 2000
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Studied role of Physalin A as an antineoplastic agent in activation of nuclear factor erythroid 2 (Nrf2) and p38 pathway and subsequent increase in quinone reductase expression.
Cadmium promotes colon cancer cell migration through ROS-dependent activation of p38 MAPK.
The authors performed a large-scale small molecule screen and found that the p38 MAPK pathway is involved in coordinating cell size and cell cycle progression. Small cells display higher p38 activity and spend more time in G1 than larger cells.
The results of the present study demonstrated that EPDMNQ and ENDMNQ induced apoptosis through ROSmodulated MAPK and STAT3 signaling pathways in Hep3B cells. Therefore, these novel 1,4naphthoquinone derivatives may be useful as anticancer agents for the treatment of liver cancer.
Study identified p38alpha and p38delta as critical regulators of ASC oligomerization, inflammasome activation, and IL-1beta secretion in keratinocytes. Furthermore, data suggest that the nature of the mitogen-activated protein kinase regulating inflammasome activity exhibits a certain cell specificity, with p38 playing a predominant role in keratinocytes and Jun N-terminal kinase 1 in cells of myeloid origin.
These findings allowed us to develop an effective strategy to attenuate the negative polybrene impact on the hMESCs properties during lentiviral infection by inhibiting the activity of p38 MAPK.
These observations indicate that p38alpha probably blocks brown adipose tissue thermogenesis through p38delta inhibition.
CT143 protein could stimulate the secretion of inflammatory cytokines in macrophages which differentiated from THP-1 This induction may be mediated by the activation of p38 signaling. In summary, CT143 protein is involved in inflammatory processes during Ct infection.
Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.
The authors results suggest that SNPs in MAPK14 is associated with the development of diabetic foot ulcers in both type 1 and type 2 diabetes mellitus.
Results show that activation of the p38/MAPK pathway may increase the expression of MICA and induce the expression of MMP-9. MMP-9 is involved in the shedding of sMICA from MICA to promote tumor immune escape. Furthermore, p38/MAPK could potentially represent a novel target for inhibiting tumor cell immune escape.
Activin A-p38 MAPK signaling in leiomyoma and myometrium may contribute to excessive extracellular matrix production, leiomyoma growth and progression
We show that the hydrogen bond between Thr185 and Asp150 is crucial in initiating the autophosphorylation reaction, providing the energy to orient the T-G-Y motif. In the mutant structure the C-terminal end of the activation loop (Tyr182 to Thr185) has a higher temperature factor than in the wild type, the activation loop (Leu171 to Val181) is highly mobile
High MAPK14 expression is associated with hepatocellular carcinoma.
Subjecting cultured satellite cells to transient inhibition of P38alpha MAP kinase in conjunction with NAC treatment leads to their rapid expansion, with striking improvement of their regenerative potential in grafting experiments.
High MAPK14 expression is associated with Breast Cancer.
p38-mediated phosphorylation at threonine 367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis.
High expression of p38MAPK is associated with diabetic cataract.
p38 capital EM, Cyrilliccapital A, Cyrilliccapital ER, Cyrilliccapital KA, Cyrillic participates in the pathogenesis of epithelial-to-mesenchymal transition through Wnt pathway.
The Cox proportional hazard models revealed that IL12Rb2 and p38MAPK predicted a long OS. To the best of our knowledge, the present study is the first to reveal a close association between IL12Rb2 and p38MAPK, and their possible function in nonsmall cell lung cancer progression
P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK, which is switched off upon entry into mitosis.
Dkk3r regulates p38a phosphorylation to maintain Smad4 stability, in turn enabling the Smad2.Smad3a.Smad4 complex to form and activate the myf5 promoter.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells
cross-talk between p(38)MAPK and Gialpha play a pivotal role for full activation of cPLA2 during ET-1 stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter involves activation of p38 and JNK MAPKs
These data suggest a differential requirement of JNK1 and p38 MAPK in TNF regulation of E2F1. Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
involvement of p38 MAP kinase activities and caldesmon phosphorylation in the MLCK-independent regulation of thrombin-induced endothelial cell permeability.
involvement of p38 MAP kinase in the hyaluronan oligosaccharide induction of MMP-13
These data indicate that early transient activation of MAPK-p38 in bovine mononuclear phagocytes by Mycobacterium avium subsp. paratuberculosis (MAP) organisms may be a key to the capacity of MAP to survive in bovine monocytes.
Replacement of distention with pharmacological relaxation reduced the increase in p38 expression, but not extracellular signal-regulated kinases.
dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms.
ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
data suggest that p38Kb may affect circadian locomotor rhythms through the regulation of multiple downstream pathways
Data show that the genetic interaction between p38b MAPK and Rack1 controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF pathway and DREF is involved in the regulation of proliferation and differentiation of Drosophila ISCs and progenitors
High p38MAPK expression is associated with abdominal aortic aneurysm.
IL-17A aggravates inflammatory response during Acute myocardial infarction by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKalpha/p38MAPK/ERK1/2 pathway.
deficiency promotes white-to-beige adipocyte reprogramming in a cell-autonomous manner
results indicate that myeloid p38alpha through the production of IGF-1 controls colon inflammation and tumorigenesis
Colonic dendritic cells regulate the differentiation of type 1 regulatory T cells through p38alpha-dependent IL-27 production to initiate an effective immune response.
Even in the presence of increased XIAP expression, inhibition of the mitogen-activated protein kinase (MAPK) p38 and MAPK-activated protein kinase 2 (MK2) made differentiated macrophages susceptible to cell death.
In conclusion, the activation of JNK and p38 after cerebral ischemia caused an increase in cerebral SGLT-1. The regulation of cerebral SGLT-1 expression via the MAPK pathway may be a novel therapeutic strategy for cerebral ischemia patients.
blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL1beta and cleavage of caspase1.
results define a key role for p38alpha in luminal progenitor cell fate that affects mammary tumor formation.
Lysosomal p38 MAPK directly phosphorylates LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating chaperone-mediated autophagy.
Results implicate neuronal p38alpha signaling in the synaptic plasticity dysfunction and memory impairment observed in 5XFAD mice, by regulating both amyloid-beta deposition in the brain and the relay of this accumulation to mount an inflammatory response, which leads to the cognitive deficits.
These findings uncovered the molecular mechanisms by which p38alpha MAPK regulates osteoclastogenesis and coordinates osteoclastogenesis and osteoblastogenesis.
Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation.
These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK.
Overall, the authors showed that CCN1 increased IL-1beta production via p38 MAPK signaling, indicating a role for CCN1 protein in regulating inflammation in psoriasis.
we have identified novel interaction between p38 MAPK and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification
p38alpha MAPK maintains the expression of antioxidant genes in liver of young animals via NF-kappaBeta under basal conditions, whereas its long-term deficiency triggers compensatory up-regulation of antioxidant enzymes through NF-kappaBeta.
cytochrome c microinjection induces p38 phosphorylation through caspase-3 activation, and caspase inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK) is essential for drug-induced COX-2 expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.
JNK plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
These findings suggest that the TQ-induced production of ROS causes dedifferentiation through the ERK pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB, p53 and caspase-3 activation.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Csaids binding protein
, MAP kinase 14
, MAP kinase 2
, MAP kinase Mxi2
, MAP kinase p38 alpha
, MAPK 14
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, mitogen-activated protein kinase 14A
, mitogen-activated protein kinase p38 alpha
, p38 MAP kinase
, p38 mitogen activated protein kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, MAP kinase 14B
, MAP kinase p38b
, MAPK 14B
, mitogen-activated protein kinase 14B
, mitogen-activated protein kinase p38b
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2
, p38 mitogen-activated kinase
, CSAIDS-binding protein 1
, stress-activated protein kinase 2a
, MAP kinase 14A
, MAP kinase p38a
, MAPK 14A
, Mitogen-activated protein kinase p38a
, mitogen-activated protein kinase p38a