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Rhesus Monkey Corticotropin Releasing Hormone Binding Protein (CRHBP) interaction partners

1. CRH/UCN-R activation promotes luteal development and/or structure-function in monkeys during the menstrual cycle.

Mouse (Murine) Corticotropin Releasing Hormone Binding Protein (CRHBP) interaction partners

1. Repeated cycles of binge drinking alter CRF-BP mRNA expression in the medial prefrontal cortex.

2. Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking.

3. These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA (show HPSE Proteins) response to stress in female mice.

4. estrogen-regulated expression of corticotropin-releasing hormone-binding protein in lactotropes in female mice suggests that the pituitary is an important site for interactions between the hypothalamic-pituitary-adrenal axis and other endocrine systems

5. Evidence is presented suggesting that the CRH-BP may be required for corticotropin-releasing factor (show CRH Proteins)-induced potentiation of NMDA receptors in dopaminergic neurons of the ventral tegmental area.

6. GnRH induces a 3.7-fold increase in CRH-BP mRNA levels via multiple intracellular signaling pathways and a multipartite GnRH response element.

7. analysis of regulation and function of CRH-BP [review]

8. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.

Human Corticotropin Releasing Hormone Binding Protein (CRHBP) interaction partners

1. A measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP.

2. We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH (show CRH Proteins) system to contribute to the development of kidney cancer.

3. Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision.

4. These results suggest that the CRH (show CRH Proteins) and CRH-BP genes have no direct effect on Irritable bowel syndrome status.

5. Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms

6. Significant main effects on children's cortisol reactivity were found for loci on CRHR1 (show CRHR1 Proteins) and CRHBP.

7. A significant association was observed in Blacks, Hispanics and Whites between birth weight and maternal CRH-BP single nucleotide polymorphism genotypes.

8. There was a significant association between the s/s homozygous genotype for the 5-HTTLPR (show SLC6A4 Proteins) polymorphism of SLC6A4 (show SLC6A4 Proteins) gene and restrained eating condition (p = 0.033

9. CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma.

10. interaction of CRHR1 (show CRHR1 Proteins) SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients