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CRH/UCN-R activation promotes luteal development and/or structure-function in monkeys during the menstrual cycle.
Repeated cycles of binge drinking alter CRF-BP mRNA expression in the medial prefrontal cortex.
Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking.
These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA response to stress in female mice.
estrogen-regulated expression of corticotropin-releasing hormone-binding protein in lactotropes in female mice suggests that the pituitary is an important site for interactions between the hypothalamic-pituitary-adrenal axis and other endocrine systems
Evidence is presented suggesting that the CRH-BP may be required for corticotropin-releasing factor-induced potentiation of NMDA receptors in dopaminergic neurons of the ventral tegmental area.
GnRH induces a 3.7-fold increase in CRH-BP mRNA levels via multiple intracellular signaling pathways and a multipartite GnRH response element.
analysis of regulation and function of CRH-BP [review]
Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP gene predicting the risk of heroin relapse in the chronically stressed subjects.
A measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP.
We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer.
Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision.
These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status.
Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms
Significant main effects on children's cortisol reactivity were found for loci on CRHR1 and CRHBP.
A significant association was observed in Blacks, Hispanics and Whites between birth weight and maternal CRH-BP single nucleotide polymorphism genotypes.
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and restrained eating condition (p = 0.033
CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma.
interaction of CRHR1 SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients
results extend recent preclinical and clinical findings implicating the CRH-BP in stress-related alcoholism and confirm the role of the Asp40 allele of the OPRM1 gene in reward-driven alcohol phenotypes
genotype analyses yielded significant association between CRHBP and suicide attempt (P = 0.035); interaction analysis showed significant interaction between CRH receptor type 1 and CRHBP in influencing suicide attempt and severity of suicidal behaviour
SNP rs10473984 affects response to citalopram in African American and Hispanic patients with major depressive disorder
Detected in myometrium. Widespread expression of CRH system in gestational tissue suggests paracrine role CRH in birth process (e.g. effects on macrophages and endothelial cells).
The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression.
The placenta was identified as the main site of the CRH-BP mRNA expression during the last weeks of pregnancy
We found a significant decrease in CRF-BP mRNA levels in the basolateral amygdala of male bipolar and male schizophrenic subjects and the lateral amygdala of male bipolar subjects compared to controls.
expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy; the most pronounced down-regulation of CRH-BP and CRH-R2 occurred in laboring cervix, irrespective the length of gestation
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
corticotropin-releasing factor-binding protein
, Corticotropin-releasing factor-binding protein
, corticotropin releasing hormone binding protein
, corticotropin-releasing factor-binding protein-like
, CRF-binding protein
, corticotropin-releasing hormone-binding protein
, corticotropin releasing hormone-binding protein
, corticotropin releasing factor binding protein
, neuropeptide binding protein