CRHBP Protein (His tag)
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- Target See all CRHBP Proteins
- CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This CRHBP protein is labelled with His tag.
- Purpose
- Recombinant Human CRHBP Protein (His Tag)
- Sequence
- Tyr25-Leu322
- Characteristics
- Recombinant Human Corticotropin-Releasing Factor-Binding Protein is produced by our Mammalian expression system and the target gene encoding Tyr25-Leu322 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CRHBP Protein
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Corticotropin Releasing Hormone Binding Protein (CRHBP) (AA 1-322) protein (GST tag)
CRHBP Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Corticotropin Releasing Hormone Binding Protein (CRHBP) (AA 25-322) protein (His tag)Crystallography grade CRHBP Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Corticotropin Releasing Hormone Binding Protein (CRHBP) (AA 22-322) protein (His tag)CRHBP Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
Corticotropin Releasing Hormone Binding Protein (CRHBP) protein (Myc-DYKDDDDK Tag)CRHBP Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150mm NaCl, pH 7.5.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))
- Alternative Name
- CRHBP (CRHBP Products)
- Synonyms
- crh-BP Protein, GB14094 Protein, zgc:91905 Protein, CRHBP Protein, CRH-BP Protein, CRF-BP Protein, CRFBP Protein, Crfbp Protein, crhbp-A Protein, gene E Protein, corticotropin releasing hormone binding protein Protein, corticotropin releasing hormone binding protein S homeolog Protein, CRHBP Protein, crhbp Protein, crh-BP Protein, Crhbp Protein, crhbp.S Protein
- Background
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Background: Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.
Synonym: Corticotropin-Releasing Factor-Binding Protein, CRF-BP, CRF-Binding Protein, Corticotropin-Releasing Hormone-Binding Protein, CRH-BP, CRHBP, CRFBP
- Molecular Weight
- 34.4 kDa
- UniProt
- P24387
- Pathways
- Negative Regulation of Hormone Secretion
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