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findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia
Data show that G protein-coupled receptor, family C, group 5, member A protein (GPRC5A) regulates oxidative stress through vanin 1 protein (VNN1).
These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR in patients with urothelial carcinoma after dosing of cisplatin
serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria.
VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children.
Our study provides strong biological evidence for the association of the identified SNP with BP and suggests that vanin-1 misfolding and degradation are the underlying molecular mechanism.
show that hepatic vanin-1 is under extremely sensitive regulation by PPARalpha and that plasma vanin activity could serve as a readout of changes in PPARalpha activity in human subjects
The X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor.
Serum vanin-1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients.
Our results suggest that vanin-1 can distinguish between chronic responders and non-responders ITP patients as well as between newly diagnosed ITP patients and healthy controls.
Alternative Splicing in VNN1 gene is associated with colorectal cancer.
Single-nucleotide polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with inflammatory bowel diseases.
Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells.
It isthe enzyme that recycles pantothenic acid (vitamin B5) generated during coenzyme A breakdown and actively involved in the progression of inflammatory reactions by generating cysteamine.
Liver contributes to Vanin-1 secretion in serum and PPARalpha is a limiting factor in serum Vnn1 production.
data do not support a major role for the Vanin 1 T26I variant in determining blood pressure level and incident ischemic events
Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls.
Urinary vanin-1, an ectoenzyme pantetheinase, distinguished diabetic patients with macroalbuminuria from those with normal albuminuria.
Vanin-1 is a specific and sensitive biomarker for renal tubular injury induced by organic solvents.
Overexpression of VNN1, an oxidative stress sensor in epithelial cells, was most strongly associated with progression to chronic immune thrombocytopenia
This study reports the design, synthesis, and biological examination of a highly sensitive bioluminogenic probe for pantetheinase with a limit of detection of 1.14 ng/mL. Starvation elevated the bioluminescence intensity of the mice due to the upregulation of the pantetheinase activity.
hese results indicate that mice lacking Vnn1 have deficiencies in compensatory repair and immune responses following toxic APAP exposure and that these mechanisms may contribute to the enhanced hepatotoxicity seen.
The data demonstrate that vanin-1/pantetheinase controls fibrosis, vasculopathy, autoimmunity, and oxidative stress in Systemic sclerosis (SSc).
oxidized LDL (Ox-LDL) can significantly induce VNN1 expression through an ERK1/2/cyclooxygenase-2 (COX-2)/PPARalpha signaling pathway.
absence of vanin-1 activity improves insulin sensitivity.
Results suggest an important role for VNN1 in regulating hepatic gluconeogenesis.
Data indicate that genetic ablation of the Vanin-1 (Vnn1) gene in SF-1 (NR5A1) transgenic mice significantly reduced the severity of neoplastic lesions in the adrenal cortex.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Data show that Vanin-1(-/-) mice better controlled inflammatory reaction and intestinal injury in either acute (NSAID administration) or chronic (Schistosoma infection) inflammation.
Data show that Vanin-1(-/-) mice, which lack cysteamine in tissues, exhibit resistance to oxidative injury induced by whole-body gamma-irradiation or paraquat.
steroidogenic factor-1 is able to bind to two sites in the Vanin-1 promoter, whereas SOX9 can bind to a single interposed site defined by DNA footprinting
Data suggest that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue, and the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease.
Vanin-1 is necessary for the formation of granulomas during host response to Coxiella burnetti but does not change bacterial clearance in vivo.
Vanin-1 regulates chondrogenesis via glutathione metabolism and is critical for accelerated chondrogenesis of ank/ank mesenchymal precursors and P(i) donor-driven chondrogenic transdifferentiation and calcification of aortic smooth muscle cells.
we investigate antioxidant-detoxifying enzymatic activities at the tissue level, comparing Vanin-1 -/- and wild-type mice
The vanin-1/cysteamine pathway contributes to the protection of islet beta cells from streptozotocin-induced death in vitro and in vivo
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
, pantetheine hydrolase
, vannin 1
, vascular non-inflammatory molecule 1
, vanin 1
, vanin 1, gene 1