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Human Monoclonal DUSP6 Primary Antibody for IF, IHC (p) - ABIN560670
Okudela, Yazawa, Woo, Sakaeda, Ishii, Mitsui, Shimoyamada, Sato, Tajiri, Ogawa, Masuda, Takahashi, Sugimura, Kitamura: Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. in The American journal of pathology 2009
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Rat (Rattus) Polyclonal DUSP6 Primary Antibody for FACS, WB - ABIN1882185
Muda, Boschert, Dickinson, Martinou, Martinou, Camps, Schlegel, Arkinstall: MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. in The Journal of biological chemistry 1996
Show all 3 Pubmed References
Human Polyclonal DUSP6 Primary Antibody for IHC - ABIN966015
Groom, Sneddon, Alessi, Dowd, Keyse: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. in The EMBO journal 1996
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Human Polyclonal DUSP6 Primary Antibody for ELISA, WB - ABIN4334835
Geetha, Mihaly, Stockenhuber, Blasi, Uhrin, Binder, Freissmuth, Breuss et al.: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ... in The Journal of biological chemistry 2011
DUSP6 expression in skeletal muscle was reduced by 43% just after exercise and remained below pre-exercise level after 2 h recovery.
Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa (show FLVCR1 Antibodies)) cells through sustained activation of both ERK1/2 and AMPKalpha (show GRK4 Antibodies).
High DUSP6 expression is associated with Lung Squamous Cell Carcinoma.
Results show that DUSP5 (show DUSP5 Antibodies) and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion.
Authors demonstrate the broad applicability of this recombination-based method and they proved its potential to identify new drug targets via the identification of the tumor suppressor DUSP6 as potential synthetic lethal target in melanoma cell lines with BRAF (show BRAF Antibodies) V600E mutations and high DUSP6 expression.
PICSAR has a role in promoting cSCC (show CYP11A1 Antibodies) progression via activation of extracellular signal-regulated kinase 1/2 (show MAPK3 Antibodies) signaling pathway by downregulating DUSP6 expression
DUSP6 rs2279574 SNPs was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.
DNA samples from each patient were genotyped for DUSP6 and TOP2A (show TOP2A Antibodies) SNPs
Suppression of the FOXA1 (show FOXA1 Antibodies)/DUSP6 signaling pathway may contribute to the development of Hirschsprung disease.
These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E-induced papillary thyroid carcinogenesis.
mitogen-activated kinase phosphatase-3 overexpression resulted in a significant reduction of hypothalamic FoxO1 (show FOXO1 Antibodies) phosphorylation after insulin (show INS Antibodies) stimulation.
DUSP6 may be a useful strategy to prevent neuronal death in neurodegenerative diseases.
This study demonstrates that dusp6 deficiency is a strong genetic factor shaping gut (show GUSB Antibodies) microbiota, and that it confers obesity protection by ameliorating the gut (show GUSB Antibodies) microbiota response to diet-mediated stress.
DUSP6 deficiency has limited impact on the regulation of energy metabolism, but impairs systemic glucose tolerance.
this study shows that CCL2 (show CCL2 Antibodies) supports the classical activation of macrophages, with miR (show MLXIP Antibodies)-9 mediated down-regulation of Dusp6 and enhanced ERK (show EPHB2 Antibodies)-mediated signal transduction possibly mediating this enhanced pro-inflammatory gene expression
Mitogen-activated protein kinase phosphatase 3 upregulation requires the activation of the Erk1/2 pathway, which correlates with the shutdown of this pathway.
MKP3 could be an important factor in the regulation of brown adipocyte differentiation.
DUSP6 regulates CD4 (show CD4 Antibodies)+ T-cell activation and differentiation by inhibiting the TCR-dependent ERK1/2 activation and restraining spontaneous colitis in IL-10 (show IL10 Antibodies)-deficient mice.
exercised obese mice had a lower expression of MKP-3 and FoxO1 (show FOXO1 Antibodies)/MKP-3 association in the liver
c-Myb (show MYB Antibodies) plays an important role in H-Ras (show HRAS Antibodies)-induced MKP-3 transcription
Dusp6 attenuates Ras (show RAB1A Antibodies)/MAPK (show MAPK1 Antibodies) signaling during regeneration and suppressing Dusp6 can enhance cardiac repair.
Lef1 (show LEF1 Antibodies) has a role in regulating Dusp6 in formation of the zebrafish posterior lateral line primordium
During fin development, dusp6, a known MAPK/ERK (show MAPK1 Antibodies) regulator, is induced in the mesoderm by FGF8 (show FGF8 Antibodies) signaling, through the PI3 (show PI3 Antibodies)/Akt (show AKT1 Antibodies) pathway.
Mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning.
Retinoic acid-dependent control of MAP kinase phosphatase-3 is necessary for early kidney development.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
MAP kinase phosphatase 3
, dual specificity protein phosphatase 6
, dual specificity protein phosphatase PYST1
, mitogen-activated protein kinase phosphatase 3
, serine/threonine specific protein phosphatase
, MAP kinase phosphatase X17C
, dual specificity phosphatase 6
, Dual specificity protein phosphatase 6
, dual specificity protein phosphatase 6-like