No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human IRAK1 Antibodies:
anti-Mouse (Murine) IRAK1 Antibodies:
anti-Rat (Rattus) IRAK1 Antibodies:
Go to our pre-filtered search.
Human Polyclonal IRAK1 Primary Antibody for IF, WB - ABIN6712081
Zeng, Zhang, Fu, Liu, Wang: Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. in European journal of pharmacology 2012
Show all 3 Pubmed References
Human Polyclonal IRAK1 Primary Antibody for IHC, WB - ABIN6712246
Zeng, Zhao, Ma, Jiang, Tu: Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. in International immunopharmacology 2012
Show all 3 Pubmed References
Human Polyclonal IRAK1 Primary Antibody for IHC (p), ELISA - ABIN544427
Cao, Henzel, Gao: IRAK: a kinase associated with the interleukin-1 receptor. in Science (New York, N.Y.) 1996
Show all 3 Pubmed References
Human Polyclonal IRAK1 Primary Antibody for WB - ABIN5663805
Teng, Luo, Yu, Chen, Huang, Chen, Xie, Zeng, Luo, Xiong, Liu, Hou, Feng: CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells. in Genes and immunity 2018
Human Polyclonal IRAK1 Primary Antibody for WB - ABIN3042847
Liu, Wang, Qian, Li: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. in International journal of molecular medicine 2014
Human Polyclonal IRAK1 Primary Antibody for ELISA, IHC - ABIN6271184
Yang, Zhou, Hu, Luo, Xie, Shen, Bian, Yin, Li, Zhang: Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. in Immunology 2017
Human Polyclonal IRAK1 Primary Antibody for ELISA, ICC - ABIN4327500
Chen, Tang, Fu, Wang, Han, Meng: Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages. in International journal of molecular medicine 2018
The results from this study indicate that expression of IRAK1 gene could explain phenotypic heterogeneity of SSc and may be involved in the pathogenesis of SSc due to its differential expression in certain subgroups.
this study shows that IRAK1 limits TLR3/4- and IFNAR-driven IL-27 production through a STAT1-dependent mechanism
The results from our case control study and the meta-analyses indicate that the IRAK1 rs3027898 C allele is significantly associated with an increased risk of RA, especially in Asians.
IRAK1 contributes to the survival of leukemic cells.
IRAK1 is one of the critical components involved in podocyte apoptosis in Diabetic nephropathy.
we have demonstrated that IRAK1 regulates liver TICs and sorafenib resistance in HCC cells through the regulation of the AP-1/AKR1B10 signaling cascade.
Data show that interleukin 1 receptor associated kinase 1 (IRAK1) inhibitors synergized with inhibitors of Pin1 peptidylprolyl isomerase (PIN1) in response to ionizing radiation.
Therefore, the IRAK4-MyD88 scaffolding function is essential for IL-1 signaling, but IRAK4 kinase activity can control IL-1 signal strength by modulating the association of IRAK4, MyD88, and IRAK1.
IRAK1 (rs3027898) SNP is associated with susceptibility to multiple sclerosis and systemic lupus erythematous.
The overexpression of miR-146a significantly increased the ErbB4 expression, decreased the expression of TRAF6, IRAK1, caspase 3, and the phosphorylation level of NF-kappaB, and also increased the Bcl-2/Bax ratio, suggesting the inhibition of inflammation and apoptosis.
our work extends the knowledge that IRAK1 is overexpressed and overactivated in CD4+ T cells from patients with SLE. The data highlight that when IRAK1 is blocked the differentiation of lupus naive CD4+ T cells into Th17 cells is repressed, suggesting therapeutic potential against SLE.
These collective data indicated that IRAK1 overexpression promotes endometrial carcinoma tumorigenesis by activating mitotic cell cycle and cell division pathways
Study identified IRAK1 and TRAF6 are direct targets of miR-146a in cervical cancer cells. Their expression is downregulated by miR-146a to promote cell viability.
The high mRNA levels of IRAK1 and IRAK4 were correlated with the development of Behcet's disease, which suggested that IRAK1 and IRAK4 might participate in the pathogenesis of Behcet's disease
MiRNA-146a rs2910164 and IRAK1 rs3027898 polymorphisms were a risk factor for predisposition to Rheumatoid Arthritis in Egyptian Population in codominant and dominant tested inheritance models, while, the miRNA-499 rs3746444 and PADI4 rs1748033 polymorphisms were a risk factor in codominant and recessive one.
Results show that the expression level of IRAK1 protein in papillary thyroid carcinoma (PTC) tissues was significantly decreased. Also, its expression level is regulated by miR-146a and miR-146b.
miR-146a suppresses the inflammatory response in human white adipocytes via targeting the expression of IRAK1 and TRAF6.
NLRC3 promoted K48-linked polyubiquitination and degradation of interleukin-1 receptor-associated kinase 1 (IRAK1).
miRNA146a expression was significantly higher in hepatitis C patients with a best cut off value 1.63 to discriminate between hepatitis C patients and healthy controls. Meanwhile, it was negatively correlated to IRAK1 and TRAF6 levels and positively correlated to viral load in hepatitis C patients.
These findings suggest that human IRAK-1 is essential downstream from TLRs but not IL-1Rs in fibroblasts, whereas it plays a redundant role downstream from both TLRs and IL-1Rs in leukocytes.
Pharmacological inhibition or siRNA mediated knockdown of IRAK1/4 attenuated Nod1-mediated activation of NF-kappaB, JNK, and the expression of proinflammatory cytokines. These results reveal that Nod1-mediated lipolysis promoted accumulation of DAG, which engaged PKCdelta and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes.
Findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IkappaB/NF-kappaB pathway, and IRAK-1 downregulation, respectively.
suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation.
The expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-kappaB, p38, and the JNK signaling pathways, was also increased by MPQP.
role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury
These findings demonstrate that Dectin-1, Irak1, and Rip2 are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 and Rip2.
MiR-146a/ MiR-146b could down-regulate the TRAF6 and IRAK1 expression and promote proliferation, migration and angiogenesis ability of endothelial progenitor cells, which could be important for recovery of patients with hyperacute ischemic stroke.
miR-146a inhibits inflammatory cytokine production in B cells through directly targeting IRAK1, suggesting a regulatory role of miR-146a in B cell-mediated periodontal inflammation.
these findings identify a transcription-independent, rapid, and nongenomic glucocorticoid suppression of TLR9 ligand-mediated IRAK1 ubiquitination as a novel mechanism for restraining acute inflammatory reactions
These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1beta/LPS-induced NF-kappaB activation by preventing polyubiquitination of TRAF6.
Data, including data from studies in knockout mice, suggest that Irak1 is involved in regulating glucose metabolism and insulin sensitivity in skeletal muscle (but not in liver and not in obesity due to high-fat diet); insulin sensitivity is 30% higher in Irak1 knockout mice on chow diet, but Irak1 deletion does not affect development of glucose intolerance due to high-fat diet.
Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src/Syk/NF-kappaB and IRAK1/AP-1 signaling.
IRAK1 is involved in TLR4-mediated downregulation of ABCA1 expression and lipid accumulation in VSMCs.
plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB and MAPK pathways
miR-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6.
miR-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 in both cardiomyocytes and inflammatory monocytic cells.
Results describe a new full-length gene model for the bovine IRAK1 gene.
ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
interleukin-1 receptor-associated kinase 1
, Pelle homolog
, interleukin-1 receptor-associated kinase-1
, pelle-like protein kinase
, interleukin receptor associated kinase 1