Browse our anti-MAP3K14 (MAP3K14) Antibodies

Human Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

1. Data show that breast cancer stem cells (BCSCs) expressed higher levels of NF-kappaB (show NFKB1 Antibodies)-inducing kinase (NIK).

2. These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1 (show CRMP1 Antibodies).

3. results suggest that changes in the relative concentrations of RelB (show RELB Antibodies), NIK:IKK1, and p100 (show CUX1 Antibodies) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show CUX1 Antibodies).

4. report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (show NFKB1 Antibodies) signaling nodes TRAF2 (show TRAF2 Antibodies), TRAF3 (show TRAF3 Antibodies), IKKalpha (show CHUK Antibodies), NIK, and NF-kappaB2/p100 (show CUX1 Antibodies); also provide a differential interactome of NIK mutants that cause immunodeficiency

5. OLFM1 (show OLFM1 Antibodies) is a negative regulator of non-canonical NF-kappaB (show NFKB1 Antibodies) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (show OLFM1 Antibodies) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (show CALR Antibodies)) patients.

6. The expression of OTUD7B (show OTUD7B Antibodies) and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (show ODZ1 Antibodies) stage. high OTUD7B (show OTUD7B Antibodies)/low NIK index can predict an good prognosis.

7. NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.

8. This study identified two novel independent loci (MAP3K14 and CARD9 (show CARD9 Antibodies)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.

9. The forced expression of NDRG2 (show NDRG2 Antibodies) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (show AKT1 Antibodies) signaling but also the non-canonical pathway by inducing NF-kappaB (show NFKB1 Antibodies)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (show PPP2R4 Antibodies)

10. NIK(+) endothelial cells may play an important role in the persistence of synovitis

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

1. Pathological activation of hepatic NIK (show MAP4K4 Antibodies) likely blocks hepatocyte replication, contributing to liver disease progression.

2. Nik (show MAP4K4 Antibodies)(-/-) mice could be useful as a spontaneous model of specific features of Eosinophilic esophagitis.

3. global or thymus-specific ablation of the NIK (show MAP4K4 Antibodies) gene results in fatal autoimmune liver disease in mice.

4. These findings highlight the importance of NIK (show MAP4K4 Antibodies) in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK (show MAP4K4 Antibodies) and Drp1 (show CRMP1 Antibodies).

5. constitutive activation of NIK (show MAP4K4 Antibodies) in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality.

6. results suggest that changes in the relative concentrations of RelB (show RELB Antibodies), NIK:IKK1, and p100 (show PATL2 Antibodies) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show PATL2 Antibodies).

7. NIK (show MAP4K4 Antibodies) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.

8. this study demonstrates that although NIK (show MAP4K4 Antibodies) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells

9. Using a novel conditional mutant of NIK (show MAP4K4 Antibodies), the authors could show in vivo that NIK (show MAP4K4 Antibodies) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.

10. NIK (show MAP4K4 Antibodies) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (show TNFRSF1A Antibodies)/RIP1 (show RALBP1 Antibodies)-dependent cell death independently of the alternative NF-kappaB (show NFKB1 Antibodies) pathway.