MAP3K14 antibody (N-Term)

Catalog No. ABIN2775274

Product Details anti-MAP3K14 Antibody

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SEAGPAAISI IAQAECENSQ EFSPTFSERI FIAGSKQYSQ SESLDQIPNN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAP3K14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 947 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: MAP3K14 (MAP3K14 Products)

Synonyms: FTDCR1B antibody, HS antibody, HSNIK antibody, NIK antibody, F23F1.4 antibody, F23F1_4 antibody, mitogen-activated protein kinase kinase kinase 14 antibody, Nik antibody, aly antibody, mitogen-activated protein kinase kinase kinase 14 antibody, MAP3K14 antibody, Map3k14 antibody, MAPKKK14 antibody

Background: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Alias Symbols: FTDCR1B, HS, HSNIK, NIK
Protein Interaction Partner: UBC, TRAF3, TRAF2, BIRC2, TRAF1, IKBKB, HSP90AA1, CHUK, TRAF6, TNAP, PELI3, TRAF5, TANK, NFKB2, ARRB2, ZFP91, EEF1A1, PEBP1, HSP90AB1, CDC37, MAP3K14, EDAR, IKBKAP, RPL6, RPL5, RIPK1, MAP3K7, MAPK3, CASP8, GRB14, GRB10, GRB7, MAP2K4, IKBKG, MAP3K8, RPL4,
Protein Size: 947

Molecular Weight: 104 kDa

Gene ID: 9020

NCBI Accession: NM_003954, NP_003945

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling